FIG. 2.

Replication kinetics of Vpr and/or MA NLS mutant viruses in infected dividing MT4 cells. The cells were infected with the different mutant viruses at an MOI of 0.01. Virus production in culture supernatants was monitored every 2 days by measuring RT activity. □, mock; ◊, NLS⁺ Vpr⁺; ○, NLS⁺ Vpr⁻; ▵, NLS⁻ Vpr⁺; ⊞, NLS⁻ Vpr⁻; ⧫, NLS⁻ Q65E; ⊕, NLS⁻ R80A.