Table 2. Heterogeneity testing of plasma metabolites (exposure) and myocardial infarction (outcome).
| Exposure ID | Traits | Outcome | Method | Cochran’s Q test | P-value |
| MR: Mendelian randomization. | |||||
| GCST90199705 | Propionylglycine levels | Myocardial infarction | MR-Egger | 26.803 | 0.141 |
| Propionylglycine levels | Myocardial infarction | Inverse variance weighted | 28.180 | 0.135 | |
| GCST90199741 | Gamma-glutamylglycine levels | Myocardial infarction | MR-Egger | 51.591 | 0.001 |
| Gamma-glutamylglycine levels | Myocardial infarction | Inverse variance weighted | 54.314 | < 0.001 | |
| GCST90199807 | Hexadecanedioate (C16-DC) levels | Myocardial infarction | MR-Egger | 13.816 | 0.877 |
| Hexadecanedioate (C16-DC) levels | Myocardial infarction | Inverse variance weighted | 14.560 | 0.880 | |
| GCST90200054 | 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels |
Myocardial infarction | MR-Egger | 22.892 | 0.153 |
| 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels |
Myocardial infarction | Inverse variance weighted | 24.746 | 0.132 | |
| GCST90200059 | Behenoyl dihydrosphingomyelin (d18:0/22:0) levels |
Myocardial infarction | MR-Egger | 63.234 | 0.004 |
| Behenoyl dihydrosphingomyelin (d18:0/22:0) levels |
Myocardial infarction | Inverse variance weighted | 64.156 | 0.005 | |
| GCST90200065 | 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) levels |
Myocardial infarction | MR-Egger | 38.608 | 0.135 |
| 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) levels |
Myocardial infarction | Inverse variance weighted | 39.854 | 0.132 | |
| GCST90200259 | Pentose acid levels | Myocardial infarction | MR-Egger | 12.371 | 0.903 |
| Pentose acid levels | Myocardial infarction | Inverse variance weighted | 14.847 | 0.831 | |
| GCST90200438 | Alpha-ketobutyrate levels | Myocardial infarction | MR-Egger | 15.134 | 0.442 |
| Alpha-ketobutyrate levels | Myocardial infarction | Inverse variance weighted | 15.936 | 0.457 | |
| GCST90200630 | X-24546 levels | Myocardial infarction | MR-Egger | 31.970 | 0.194 |
| X-24546 levels | Myocardial infarction | Inverse variance weighted | 32.002 | 0.232 | |
| GCST90200680 | 5-acetylamino-6-formylamino-3- methyluracil levels |
Myocardial infarction | MR-Egger | 24.809 | 0.209 |
| 5-acetylamino-6-formylamino-3- methyluracil levels |
Myocardial infarction | Inverse variance weighted | 26.147 | 0.201 | |
| GCST90200707 | Glycine levels | Myocardial infarction | MR-Egger | 18.505 | 0.554 |
| Glycine levels | Myocardial infarction | Inverse variance weighted | 20.212 | 0.508 | |
| GCST90200726 | N-acetylputrescine to (N (1) + N (8))- acetylspermidine ratio |
Myocardial infarction | MR-Egger | 29.144 | 0.510 |
| N-acetylputrescine to (N (1) + N (8))- acetylspermidine ratio |
Myocardial infarction | Inverse variance weighted | 33.031 | 0.368 | |
| GCST90200758 | Glycine to serine ratio | Myocardial infarction | MR-Egger | 47.379 | 0.002 |
| Glycine to serine ratio | Myocardial infarction | Inverse variance weighted | 48.324 | 0.002 | |
| GCST90200782 | Mannose to trans-4-hydroxyproline ratio | Myocardial infarction | MR-Egger | 15.822 | 0.779 |
| Mannose to trans-4-hydroxyproline ratio | Myocardial infarction | Inverse variance weighted | 15.901 | 0.821 | |