Table 4. Heterogeneity testing of myocardial infarction (exposure) and plasma metabolites (outcome).

Exposures	Outcome ID	Outcome traits	Method	Cochran’s Q test	P-value
MR: Mendelian randomization.
Myocardial infarction	GCST90199705	Propionylglycine levels	MR-Egger	52.343	0.967
		Propionylglycine levels	Inverse variance weighted	52.355	0.973
Myocardial infarction	GCST90199741	Gamma-glutamylglycine levels	MR-Egger	65.633	0.717
		Gamma-glutamylglycine levels	Inverse variance weighted	65.707	0.743
Myocardial infarction	GCST90199807	Hexadecanedioate (C16-DC) levels	MR-Egger	77.905	0.326
		Hexadecanedioate (C16-DC) levels	Inverse variance weighted	80.242	0.289
Myocardial infarction	GCST90200054	1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels	MR-Egger	111.559	0.002
		1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels	Inverse variance weighted	112.444	0.003
Myocardial infarction	GCST90200059	Behenoyl dihydrosphingomyelin (d18:0/22:0) levels	MR-Egger	127.943	< 0.001
		Behenoyl dihydrosphingomyelin (d18:0/22:0) levels	Inverse variance weighted	138.022	< 0.001
Myocardial infarction	GCST90200065	1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) levels	MR-Egger	87.804	0.114
		1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) levels	Inverse variance weighted	87.951	0.128
Myocardial infarction	GCST90200259	Pentose acid levels	MR-Egger	79.913	0.271
		Pentose acid levels	Inverse variance weighted	81.123	0.267
Myocardial infarction	GCST90200438	Alpha-ketobutyrate levels	MR-Egger	61.234	0.835
		Alpha-ketobutyrate levels	Inverse variance weighted	67.340	0.694
Myocardial infarction	GCST90200630	X-24546 levels	MR-Egger	79.854	0.273
		X-24546 levels	Inverse variance weighted	83.796	0.204
Myocardial infarction	GCST90200680	5-acetylamino-6-formylamino-3- methyluracil levels	MR-Egger	92.405	0.006
		5-acetylamino-6-formylamino-3- methyluracil levels	Inverse variance weighted	92.425	0.007
Myocardial infarction	GCST90200707	Glycine levels	MR-Egger	71.775	0.519
		Glycine levels	Inverse variance weighted	71.813	0.550
Myocardial infarction	GCST90200726	N-acetylputrescine to (N (1) + N (8))- acetylspermidine ratio	MR-Egger	78.894	0.298
		N-acetylputrescine to (N (1) + N (8))- acetylspermidine ratio	Inverse variance weighted	79.293	0.316
Myocardial infarction	GCST90200758	Glycine to serine ratio	MR-Egger	67.296	0.666
		Glycine to serine ratio	Inverse variance weighted	67.315	0.696
Myocardial infarction	GCST90200782	Mannose to trans-4-hydroxyproline ratio	MR-Egger	66.268	0.698
		Mannose to trans-4-hydroxyproline ratio	Inverse variance weighted	66.913	0.708