Table 5.
Logistic regression analysis of TNF-α rs1800629 G>A gene polymorphism using different inheritance models for prediction of susceptibility to COVID-19.
| Genotypes | COVID-19 Patients (N=115) |
Control Group
(N=115) |
Odd Ratio
OR (95% CI) |
Risk Ratio
RR (95% CI) |
P value |
|---|---|---|---|---|---|
| Codominant Inheritance Model | - | - | - | ||
| TNF-α-GG | 75 | 93 | 1(Ref.) | 1(Ref.) | - |
| TNF-α-GA | 35 | 20 | 2.17(1.158- 4.066) | 1.42(1.097-1.851) | 0.01 |
| TNF-α-AA | 5 | 2 | 3.1(0.58 – 16.43) | 1.6 (0.9725-2.632) | 0.157 |
| Dominant Inheritance Model | - | - | - | ||
| TNF-α-GG | 75 | 93 | 1(Ref.) | 1(Ref.) | - |
| TNF-α (GA+AA) | 40 | 22 | 2.25(1.234-4.119) | 1.44 (1.125 - 1.855) | 0.005 |
| Recessive Inheritance Model | - | - | - | ||
| TNF-α -(GG+GA) | 110 | 113 | 1(Ref.) | 1(Ref.) | - |
| TNF-α-AA | 5 | 2 | 2.56(0.48 to 13.51 | 1.44(0.8897-2.3467) | 0.26 |
| Allele | - | - | - | - | - |
| TNF-α-G | 185 | 206 | 1(Ref.) | 1(Ref.) | - |
| TNF-α-A | 45 | 24 | 2.08(1.22-3.5603) | 1.378(1.126–1.68) | 0.006 |
| Over Dominant Inheritance Model | - | - | - | ||
| TNF-α-(GG+AA) | 80 | 95 | 1(Ref.) | 1(Ref.) | - |
| TNF-α (GA) | 35 | 20 | 2.07(1.112 to 3.81) | 1.39(1.076 to 1.79) | 0.021 |