Table 5.
Immunization of Tau or antigenic peptides.
Vaccine | Target | Animal Model | Clinical Trial | Effect(s) | References |
AAD vac1 | Tau phosphorylation | Yes | Yes NCT02031198 NCT02579252 NCT01850238 |
Lower hippocampal atrophy (less cognitive decline) |
[349-354] |
Others | Tau phosphorylation/aggregates | Yes | No | Unknown | [355] |