Source	Search strategy	Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois)	narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone	June 2012:13 June 2013: 2 June 2014: 0
2. MEDLINE In‐Process & Other Non‐Indexed Citations and MEDLINE 1950 to present (OvidSP)	1. exp Dementia/ 2. Delirium/ 3. Wernicke Encephalopathy/ 4. Delirium, Dementia, Amnestic, Cognitive Disorders/ 5. dement*.mp. 6. alzheimer*.mp. 7. (lewy* adj2 bod*).mp. 8. deliri*.mp. 9. (chronic adj2 cerebrovascular).mp. 10. ("organic brain disease" or "organic brain syndrome").mp. 11. ("normal pressure hydrocephalus" and "shunt*").mp. 12. "benign senescent forgetfulness".mp. 13. (cerebr* adj2 deteriorat*).mp. 14. (cerebral* adj2 insufficient*).mp. 15. (pick* adj2 disease).mp. 16. (creutzfeldt or jcd or cjd).mp. 17. huntington*.mp. 18. binswanger*.mp. 19. korsako*.mp. 20. or/1‐19 21. Narcotics/ 22. *Analgesics, Opioid/ 23. narcotic*.ti,ab. 24. opioid*.ti,ab. 25. morphine.ti,ab. 26. Morphine/ 27. buprenorphine.ti,ab. 28. Buprenorphine/ 29. codeine.ti,ab. 30. Codeine/ 31. Dextromoramide/ 32. dextromoramide.ti,ab. 33. diphenoxylate.ti,ab. 34. Diphenoxylate/ 35. dipipanone.ti,ab. 36. dextropropoxyphene.ti,ab. 37. Dextropropoxyphene/ 38. propoxyphene.ti,ab. 39. diamorphine.ti,ab. 40. dihydrocodeine.ti,ab. 41. alfentanil.ti,ab. 42. Alfentanil/ 43. fentanyl.ti,ab. 44. Fentanyl/ 45. remifentanil.ti,ab. 46. meptazinol.ti,ab. 47. methadone.ti,ab. 48. Methadone/ 49. nalbuphine.ti,ab. 50. Nalbuphine/ 51. oxycodone.ti,ab. 52. Oxycodone/ 53. papaveretum.ti,ab. 54. Opium/ 55. pentazocine.ti,ab. 56. Pentazocine/ 57. meperidine.ti,ab. 58. Meperidine/ 59. pethidine.ti,ab. 60. phenazocine.ti,ab. 61. Phenazocine/ 62. Hydrocodone/ 63. hydrocodone.ti,ab. 64. hydromorphone/ 65. hydromorphone.ti,ab. 66. Levorphanol/ 67. levorphanol.ti,ab. 68. oxymorphone.ti,ab. 69. Oxymorphone/ 70. butorphanol.ti,ab. 71. butorphanol/ 72. dezocine.ti,ab. 73. sufentanil.ti,ab. 74. Sufentanil/ 75. ketobemidone.ti,ab. 76. or/21‐75 77. 20 and 76 78. randomized controlled trial.pt. 79. controlled clinical trial.pt. 80. randomi?ed.ab. 81. placebo.ab. 82. drug therapy.fs. 83. randomly.ab. 84. trial.ab. 85. groups.ab. 86. or/78‐85 87. (animals not (humans and animals)).sh. 88. 86 not 87 89. 77 and 88	June 2012: 312 June 2013: 51 June 2014: 43
3. EMBASE 1980 to 2012 June 11 (OvidSP)	1. exp dementia/ 2. Lewy body/ 3. delirium/ 4. Wernicke encephalopathy/ 5. cognitive defect/ 6. dement*.mp. 7. alzheimer*.mp. 8. (lewy* adj2 bod*).mp. 9. deliri*.mp. 10. (chronic adj2 cerebrovascular).mp. 11. ("organic brain disease" or "organic brain syndrome").mp. 12. "supranuclear palsy".mp. 13. ("normal pressure hydrocephalus" and "shunt*").mp. 14. "benign senescent forgetfulness".mp. 15. (cerebr* adj2 deteriorat*).mp. 16. (cerebral* adj2 insufficient*).mp. 17. (pick* adj2 disease).mp. 18. (creutzfeldt or jcd or cjd).mp. 19. huntington*.mp. 20. binswanger*.mp. 21. korsako*.mp. 22. CADASIL.mp. 23. or/1‐22 24. narcotic agent/ 25. narcotic analgesic agent/ 26. narcotic*.ti,ab. 27. opioid*.ti,ab. 28. morphine.ti,ab. 29. morphine/ 30. buprenorphine.ti,ab. 31. buprenorphine/ 32. codeine.ti,ab. 33. codeine/ 34. dextromoramide/ 35. dextromoramide.ti,ab. 36. diphenoxylate.ti,ab. 37. diphenoxylate/ 38. dipipanone.ti,ab. 39. dipipanone/ 40. dextropropoxyphene.ti,ab. 41. dextropropoxyphene/ 42. propoxyphene.ti,ab. 43. diamorphine.ti,ab. 44. dihydrocodeine.ti,ab. 45. alfentanil.ti,ab. 46. alfentanil/ 47. fentanyl.ti,ab. 48. fentanyl/ 49. remifentanil.ti,ab. 50. remifentanil/ 51. meptazinol.ti,ab. 52. meptazinol/ 53. methadone.ti,ab. 54. Methadone/ 55. nalbuphine.ti,ab. 56. Nalbuphine/ 57. oxycodone.ti,ab. 58. Oxycodone/ 59. papaveretum.ti,ab. 60. Opium/ 61. pentazocine.ti,ab. 62. Pentazocine/ 63. hydrocodone.ti,ab. 64. Hydrocodone/ 65. hydromorphone.ti,ab. 66. Hydromorphone/ 67. Levorphanol/ 68. Levorphanol.ti,ab. 69. oxymorphone.ti,ab. 70. Oxymorphone/ 71. butorphanol.ti,ab. 72. Butorphanol/ 73. dezocine.ti,ab. 74. sufentanil.ti,ab. 75. Sufentanil/ 76. ketobemidone.ti,ab. 77. or/24‐76 78. 23 and 77 79. Randomized Controlled Trial/ 80. Controlled Clinical Trial/ 81. randomi?ed.ab. 82. placebo.ab. 83. drug therapy.fs. 84. randomly.ab. 85. trial.ab. 86. groups.ab. 87. ("double‐blind*" or "single‐blind*").ti,ab. 88. or/79‐87 89. 78 and 88	June 2012: 309 June 2013: 151 June 2014: 72
4. PsycINFO 1806 to June week 1 2012 (Ovid SP)	1. exp Dementia/ 2. exp Delirium/ 3. exp Huntingtons Disease/ 4. exp Kluver Bucy Syndrome/ 5. exp Wernickes Syndrome/ 6. exp Cognitive Impairment/ 7. dement*.mp. 8. alzheimer*.mp. 9. (lewy* adj2 bod*).mp. 10. deliri*.mp. 11. (chronic adj2 cerebrovascular).mp. 12. ("organic brain disease" or "organic brain syndrome").mp. 13. "supranuclear palsy".mp. 14. ("normal pressure hydrocephalus" and "shunt*").mp. 15. "benign senescent forgetfulness".mp. 16. (cerebr* adj2 deteriorat*).mp. 17. (cerebral* adj2 insufficient*).mp. 18. (pick* adj2 disease).mp. 19. (creutzfeldt or jcd or cjd).mp. 20. huntington*.mp. 21. binswanger*.mp. 22. korsako*.mp. 23. ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp. 24. or/1‐23 25. Narcotic Drugs/ 26. exp Opiates/ 27. narcotic*.ti,ab. 28. opioid*.ti,ab. 29. morphine.ti,ab. 30. exp Morphine/ 31. buprenorphine.ti,ab. 32. codeine.ti,ab. 33. Codeine/ 34. dextromoramide.ti,ab. 35. dipipanone.ti,ab. 36. dextropropoxyphene.ti,ab. 37. propoxyphene.ti,ab. 38. diamorphine.ti,ab. 39. dihydrocodeine.ti,ab. 40. alfentanil.ti,ab. 41. fentanyl.ti,ab. 42. remifentanil.ti,ab. 43. meptazinol.ti,ab. 44. methadone.ti,ab. 45. Methadone/ 46. nalbuphine.ti,ab. 47. oxycodone.ti,ab. 48. papaveretum.ti,ab. 49. pentazocine.ti,ab. 50. meperidine.ti,ab. 51. pethidine.ti,ab. 52. phenazocine.ti,ab. 53. Hydrocodone.ti,ab. 54. hydromorphone.ti,ab. 55. levorphanol.ti,ab. 56. oxymorphone.ti,ab. 57. butorphanol.ti,ab. 58. dezocine.ti,ab. 59. sufentanil.ti,ab. 60. ketobemidone.ti,ab. 61. or/25‐60 62. 24 and 61 63. randomi?ed.ab. 64. placebo.ab. 65. randomly.ab. 66. trial.ab. 67. groups.ab. 68. RCT.ti,ab. 69. ("double‐blind*" or "single‐blind*").ti,ab. 70. exp Clinical Trials/ 71. or/63‐70 72. 62 and 71	June 2012: 68 June 2013: 6 June 2014: 12
5. CINAHL (EBSCOhost)	S1 (MH “Dementia+”) S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders")  S3 (MH "Wernicke's Encephalopathy") S4 TX dement* S5 TX alzheimer* S6 TX lewy* N2 bod* S7 TX deliri* S8 TX chronic N2 cerebrovascular S9 TX "organic brain disease" or "organic brain syndrome" S10 TX "normal pressure hydrocephalus" and "shunt*" S11 TX "benign senescent forgetfulness" S12 TX cerebr* N2 deteriorat* S13 TX cerebral* N2 insufficient* S14 TX pick* N2 disease S15 TX creutzfeldt or jcd or cjd S16 TX huntington* S17 TX binswanger* S18 TX korsako* S19 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18 S20 (MH "Narcotics") S21 (MH "Analgesics, Opioid") S22 TX narcotic* S23 TX opioid* S24 TX morphine S25 (MH "Morphine") S26 TX buprenorphine S27 (MH "Buprenorphine") S28 TX codeine S29 codeine S30 (MH "Codeine") S31 TX Dextromoramide S32 TX diphenoxylate S33 (MH "Diphenoxylate") S34 TX dextropropoxyphene S35 TX propoxyphene S36 TX diamorphine S37 TX dihydrocodeine S38 TX alfentanil S39 TX fentanyl S40 TX remifentanil S41 TX meptazinol S42 TX methadone S43 TX nalbuphine S44 TX oxycodone S45 TX papaveretum S46 (MH "Opium") S47 TX pentazocine S48 TX meperidine S49 TX pethidine S50 TX phenazocine S51 TX hydrocodone S52 TX hydromorphone S53 TX levorphanol S54 TX oxymorphone S55 TX butorphanol S56 TX dezocine S57 TX sufentanil S58 TX ketobemidone S59 S20 or S21 or S22 or S23 or S24 or S25 or S26 or S27 or S28 or S29 or S30 or S31 or S32 or S33 or S34 or S35 or S36 or S37 or S38 or S39 or S40 or S41 or S42 or S43 or S44 or S45 or S46 or S47 or S48 or S49 or S50 or S51 or S52 or S53 or S54 or S55 or S56 or S57 or S58 S60 S19 and S59 S61 TX placebo S62 TX randomly S63 TX trial S64 TX groups S65 (MH "Clinical Trials") S66 TX "double‐blind*" OR "single‐blind*" S67 S61 or S62 or S63 or S64 or S65 or S66 S68 S60 and S67	June 2012: 162 June 2013: 13 June 2014: 23
6. CENTRAL (The Cochrane Library for June 2012 and June 2013 searches and CRSO for June 2014)	#1 MeSH descriptor Dementia explode all trees #2 MeSH descriptor Delirium, this term only #3 MeSH descriptor Wernicke Encephalopathy, this term only #4 MeSH descriptor Delirium, Dementia, Amnestic, Cognitive Disorders, this term only #5 dement* #6 alzheimer* #7 "lewy* bod*" #8 deliri* #9 "chronic cerebrovascular" #10 "organic brain disease" or "organic brain syndrome" #11 "normal pressure hydrocephalus" and "shunt*" #12 "benign senescent forgetfulness" #13 "cerebr* deteriorat*" #14 "cerebral* insufficient*" #15 "pick* disease" #16 creutzfeldt or jcd or cjd #17 huntington* #18 binswanger* #19 korsako* #20 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19) #21 MeSH descriptor Narcotics explode all trees #22 MeSH descriptor Analgesics, Opioid, this term only #23 narcotic* #24 opioid* #25 morphine #26 MeSH descriptor Morphine, this term only #27 buprenorphine #28 MeSH descriptor Buprenorphine, this term only #29 codeine #30 MeSH descriptor Codeine, this term only #31 dextromoramide #32 diphenoxylate #33 MeSH descriptor Diphenoxylate, this term only #34 dipipanone #35 dextropropoxyphene #36 MeSH descriptor Dextropropoxyphene, this term only #37 propoxyphene #38 diamorphine #39 dihydrocodeine #40 alfentanil #41 fentanyl #42 remifentanil #43 meptazinol #44 methadone #45 MeSH descriptor Methadone, this term only #46 nalbuphine #47 oxycodone #48 papaveretum #49 MeSH descriptor Opium, this term only #50 pentazocine #51 MeSH descriptor Pentazocine, this term only #52 meperidine #53 pethidine #54 phenazocine #55 MeSH descriptor Phenazocine, this term only #56 MeSH descriptor Hydrocodone, this term only #57 hydrocodone #58 MeSH descriptor Hydromorphone, this term only #59 hydromorphone #60 MeSH descriptor Levorphanol, this term only #61 levorphanol #62 oxymorphone #63 MeSH descriptor Oxymorphone, this term only #64 butorphanol #65 MeSH descriptor Butorphanol, this term only #66 dezocine #67 sufentanil #68 MeSH descriptor Sufentanil, this term only #69 ketobemidone #70(#21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 OR #54 OR #55 OR #56 OR #57 OR #58 OR #59 OR #60 OR #61 OR #62 OR #63 OR #64 OR #65 OR #66 OR #67 OR #68 OR #69) #71 (#20 AND #70) [2012‐2013]	June 2012: 100 June 2013: 3 June 2014: 1
7. LILACs (Bireme)	demenc$ OR dement$ OR vascular OR VCI OR Vad OR CADASIL OR multi‐infarct OR binswanger OR alzheimer OR alzheimers [Words] and narcotic OR narcotics OR opiate OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone [Words] and placebo OR randomly OR randomised OR randomized OR "double‐blind" OR "double‐blinded" OR "control group" OR RCT [Words]	June 2012: 3 June 2013: 3 June 2014: 0
8. ClinicalTrials.gov	Interventional Studies | dementia OR alzheimers OR AD OR alzheimer's OR alzheimer OR lewy OR FTLD OR FLD | methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone OR narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol	June 2012: 9 June 2013: 4 June 2014: 4
9. ICTRP Search Portal (http://apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register]	Advanced search: (dementia OR alzheimers OR alzheimer's OR alzheimer OR lewy OR FTLD) AND (methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone OR narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol): recruitement status: ALL	June 2012: 4 June 2013: 0 June 2014: 0
10. Web of Science and Conference Proceedings	Topic=(dementia OR alzheimer* OR AD OR lewy OR memory OR CJD OR JCD OR creutzfeldt OR binswanger OR korsakoff OR aMCI) AND Topic=(narcotic* OR opioid* OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone) AND Topic=(randomised OR randomized OR randomly or placebo or "double‐blind" or trial OR groups OR "controlled study" OR RCT OR "single‐blind*") Timespan=All Years. Search language=English Lemmatization=On	June 2012: 416 June 2013: 66 June 2014: 42
Total pre‐deduplication for all three searches		1892
Total after de‐duplication		1077
Total after first assess based to title and abstract screen		50