Matijevic 2006.
Methods | Randomisation was by a computer‐generated table of random numbers. Allocation concealment through sealed opaque envelopes. Blinding: women blinded to allocation through use of a placebo. Losses to follow up: none reported. |
|
Participants | 120 women who met the following inclusion criteria: singleton pregnancy; gestational age 24‐34 weeks; > 5 contractions per hour for 2 hours; modified bishop score > 3. | |
Interventions | Following successful parenteral tocolysis, women were randomly assigned to ritodrine (80 mg 3 times per day) or placebo. | |
Outcomes | Preterm birth < 34 weeks; preterm birth < 37 weeks; preterm birth in 72 hours; infant birthweight; perinatal mortality; NICU admission; Apgar score < 7 at 5 minutes; mechanical ventilation; maternal side effects (pulmonary oedema, tremor, tachycardia, shortness of breath). | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random number table. |
Allocation concealment (selection bias) | Low risk | Sealed opaque envelopes. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not stated. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No reported losses to follow‐up. |
Selective reporting (reporting bias) | Unclear risk | Unable to assess. |
Other bias | Low risk |