Table 2.
Linear association of cardiometabolic biomarkers over clinical trajectories
|
Predictors
β (95%CI) |
BMI
(N=559) |
WC
(N= 532) |
TG
(N=474) |
Reversed HDL
(N=474) |
LDL
(N=467) |
HbA1c
(N=456) |
DBP
(N=546) |
SBP
(N=546) |
PR
(N=544) |
MCS
(N=404) |
|---|---|---|---|---|---|---|---|---|---|---|
| A. Cognitive trajectory | ||||||||||
| High | -1.24 (-2.28-0.20)** | -3.25 (-8.03,1.79) | Removed | Removed | Removed | Removed | -2.71 (-5.59,0.17)⁎ | Removed | Removed | -0.07(-0.52,0.38) |
| Normal | -1.54 (-3.28,0.85)* | -2.55 (-5.57,0.46) | Removed | -0.11 (-0.24,0.02) | Removed | Removed | Removed | Removed | Removed | -0.21(-0.48,0.06) |
| Mild | Removed | Removed | Removed | Removed | Removed | Removed | 1.84 (-0.11,3.78) ⁎ | 2.74 (0.11,5.37)** | 1.36(-1.93,4.65) | Removed |
| Moderate | Removed | Removed | 0.54 (0.17,0.92)*** | Removed | Removed | Removed | Removed | Removed | 4.31(-0.54,9.15)⁎ | Removed |
| Severe | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed |
| B. Positive symptoms trajectory | ||||||||||
| Low | Removed | Removed | Removed | Removed | Removed | -2.01(-3.21, -0.82)** | Removed | Removed | -2.25(-5.17, -0.67) | Removed |
| Moderate | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed |
| High | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed |
| C. Negative symptoms trajectory | ||||||||||
| Low | Removed | Removed | Removed | -0.11 (-0.24,0.02) | Removed | Removed | Removed | Removed | Removed | -0.20(-0.43,0.03)⁎ |
| High-Decreased | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed |
| High-Increased | Removed | Removed | Removed | Removed | Removed | Removed | Removed | -3.92(-7.66,-0.17)** | Removed | Removed |
| D. Covariates | ||||||||||
| Age | 0.02 (-0.04, 0.08) | 0.21 (0.03, 0.38)** | 0.01 (-0.01, 0.03) | 0.01 (0.00, 0.02)* | 0.03 (0.02, 0.04)*** | 0.22 (0.14, 0.30)*** | 0.17 (0.05, 0.29)** | 0.14 (-0.03, 0.31) | -0.25(-0.44,-0.05)** | 0.03(0.01,0.04)*** |
| Gender (Female) | 0.30 (-0.32, 1.23) | -4.56 (-7.19, -1.92)*** | -0.55 (-0.87, 0.22)*** | -0.26 (-0.40, -0.11)*** | -0.08 (-0.28, 0.12) | -1.69 (-3.02, -0.36)** | -0.99 (-3.14, 1.17) | -9.41 (-12.39, -6.42)*** | 1.42(-1.63,4.47) | -0.62(-0.86,-0.39)*** |
| Ethnicity (Caucasian) | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed |
| IQ | -0.03 (-0.06,0.00)* | -0.12(-0.21,-0.02)** | Removed | Removed | Removed | Removed | Removed | Removed | -0.09 (-0.19, 0.01)⁎ | -0.01 (-0.02, 0.00)⁎ |
| Illness duration | 0.19 (0.10, 0.29)*** | 0.37(0.10, 0.65)** | Removed | Removed | Removed | Removed | Removed | Removed | 0.50(0.18,0.81)** | Removed |
| Education | Removed | Removed | Removed | Removed | Removed | Removed | -0.27 (-0.50, -0.04)** | Removed | Removed | Removed |
| Cigarettes use | Removed | Removed | Removed | Removed | Removed | Removed | Removed | Removed | 0.10(0.02,0.19)** | Removed |
| Alcohol use | Removed | Removed | Removed | Removed | 0.01 (0.00, 0.01)* | Removed | 0.08(-0.00,0.16) ⁎ | Removed | Removed | Removed |
Abbreviations: β: effect size; CI: Confidence Interval; BMI: body mass index; WC: waist circumference; TG: Triglycerides; HDL: Reversed High density lipoprotein; LDL: Low density lipoprotein; HbA1c: Glycated haemoglobin; DBP: Diastolic blood pressure; SBP: Systolic blood pressure; PR: Pulse rate; MCS: Metabolic composite score
Removed: The variable was excluded from the final model
N: sample size of the model fitting
Significance level: ***: P-value < 0.001; **: P-value < 0.05; ⁎: P-value < 0.1