Table 4. Evaluation of demographic data with using univariate and multivariate analyzes.

Variables	n	%	Univariate analyzes		Multivariate analyzes
			p	Hazard ratio	p	Hazard ratio
Age (>65 years)	55	28.8	0.19	1.3	0.41	0.79
Tobacco use	162	84.8	0.59	0.87	0.42	1.35
Histology
Squamous cell carcinoma	61	31.9	ref	ref	ref	ref
Adenocarcinoma	66	34.5	0.15	0.72	0.44	0.52
Large cell carcinoma	64	33.5	0.18	0.74	0.32	0.43
PD-1 expression on cancer cells	62	32.5	<0.001	2.60	0.01	3.39
PD-1 expression on lymphocytes	102	53.4	<0.001	2.86	0.73	1.15
Necrosis	88	46.1	<0.001	3.45	0.011	1.02
Stage
I	80	41.9	ref	ref	ref	ref
II	50	26.2	<0.001	2.69	0.002	3.35
III	61	31.9	<0.001	3.61	<0.001	4.87
SD: Standard deviation; Ref: Reference value.