TABLE 2.
Differences in COVID-19 severity between non-pregnant and pregnant patients
| Variable | Pregnant | First trimester | Second trimester | Third trimester | Non-pregnant | Odds pregnant vs non-pregnant total (CI) | P-value |
|---|---|---|---|---|---|---|---|
| N | 117 | 28 | 36 | 53 | 335 | ||
| Symptomatic total, n (%) | 91 (77.7%) | 25 (89.3%) | 32 (88.9%) | 34 (64.1%) | 300 (89.6%) | 0.41 (0.23–0.71) | 0.003 |
| Unvaccinated, n (%) | 63 (69.2%) | 18 (72.0%) | 24 (75.0%) | 21 (61.8%) | 220 (73.3%) | 0.33 (0.17–0.61) | 0.0014 |
| Vaccinated, n (%) | 28 (30.8%) | 7 (28.0%) | 8 (25.0%) | 13 (38.2%) | 80 (26.7%) | 0.77 (0.26–2.1) | 0.76 |
| Hospitalization total, n (%) | 17 (14.5%) | 0 (0.0%) | 3 (8.3%) | 14 (26.4%) | 13 (3.9%) | 4.2 (2.0–8.6) | 0.0003 |
| Unvaccinated, n (%) | 12 (70.6%) | 0 (0.0%) | 2 (16.7%) | 10 (83.3%) | 13 (100%) | 5.9 (2.6–12.8) | <0.0001 |
| Vaccinated, n (%) | 5 (29.4%) | 0 (0.0%) | 1 (20.0%) | 4 (80.0%) | 0 (0.0%) | 37.7 (2.0–706.6) | 0.0009 |
| COVID reason for admission total, n (%) | 13 (11.1%) | 0 (0.0%) | 2 (5.6%) | 11 (20.7%) | 13 (3.9%) | 3.1 (1.4–6.8) | 0.009 |
| Unvaccinated, n (%) | 10 (76.9%) | 0 (0.0%) | 2 (100%) | 8 (72.7%) | 13 (100%) | 3.0 (1.2–7.4) | 0.017 |
| Vaccinated, n (%) | 3 (23.1%) | 0 (0.0%) | 0 (0.0%) | 3 (27.2%) | 0 (0.0%) | 24.0 (1.2–481.0) | 0.013 |
| ICU admittance total, n (%) | 6 (5.1%) | 0 (0.0%) | 1 (2.8%) | 5 (9.4%) | 4 (1.2%) | 4.5 (1.2–14.2) | 0.02 |
| Unvaccinated, n (%) | 3 (50.0%) | 0 (0.0%) | 0 (0.0%) | 3 (60.0%) | 3 (75.0%) | 3.6 (0.8–15.6) | 0.13 |
| Vaccinated, n (%) | 3 (50.0%) | 0 (0.0%) | 1 (100%) | 2 (40.0%) | 1 (25.0%) | 26.3 (3.7–341.9) | 0.005 |
| Supplemental O2, n (%) | 11 (9.4%) | 0 (0.0%) | 2 (5.6%) | 9 (17.0%) | 11 (3.3%) | 3.1 (1.3–6.9) | 0.01 |
| Unvaccinated, n (%) | 7 (63.6%) | 0 (0.0%) | 2 (100.0%) | 5 (55.6%) | 11 (100.0%) | 2.4 (9.2–6.4) | |
| Vaccinated, n (%) | 4 (36.4%) | 0 (0.0%) | 0 (0.0%) | 4 (44.4%) | 0 (0.0%) | 29.6 (1.5–568.7) | 0.004 |