Figure 1.

Multivariable linear regression analysis of all relapses (primary analysis) irrespective of relapse phenotype. Dependent variable (outcome): change in EDSS from first assessment at relapse to EDSS after the last relapse treatment. Independent variables: sex, age at relapse, smoking status (yes versus no), total EDSS at relapse, administered steroid dosage (up to 3 g methyl prednisolone equivalent versus more than 3 g), plasma exchange treatment for current relapse (yes versus no), and disease-modifying treatment at relapse (yes versus no). n = 134 events, adjusted Nagelkerke’s R² 0.27, variance inflation factor for all independent variables below 1.8. Significant associations for female sex, age at relapse, and EDSS at relapse, all other investigated independent variables did not demonstrate a significant association with EDSS change (Supplemental Table 1).

95% CI, 95% confidence interval; EDSS, expanded disability status scale; PLEX, plasma exchange.