Table 3.
Casual effects of MR Analysis between GM and T1DN/T2DN (P value corrected by FDR).
| Outcome | Level | Exposure | Method | NO.SNP | P | PFDR |
|---|---|---|---|---|---|---|
| T1DN | genus | Eubacteriumcoprostanoligenesgroup | IVW | 13 | 0.000783 | 0.002125763 |
| MR Egger | 0.120655 | 0.327492218 | ||||
| WM | 0.002616 | 0.007100466 | ||||
| T2DN | family | Verrucomicrobiaceae | IVW | 11 | 0.002196 | 0.008343025 |
| MR Egger | 0.709418 | 2.695786857 | ||||
| WM | 0.084151 | 0.319773891 | ||||
| order | Verrucomicrobiales | IVW | 11 | 0.002187 | 0.002444585 | |
| MR Egger | 0.706851 | 0.790009472 | ||||
| WM | 0.090536 | 0.101187786 | ||||
| Rhodospirillales | IVW | 11 | 0.002196 | 0.002607195 | ||
| MR Egger | 0.082865 | 0.842433393 | ||||
| WM | 0.709418 | 0.098402182 | ||||
| class | Verrucomicrobiae | IVW | 11 | 0.002187 | 0.013852647 | |
| MR Egger | 0.706851 | 4.47672034 | ||||
| WM | 0.075537 | 0.478403913 | ||||
| phylum | Proteobacteria | IVW | 12 | 0.002858 | 0.002857644 | |
| MR Egger | 0.697337 | 0.697336558 | ||||
| WM | 0.047523 | 0.047522824 |
No. SNP is the number of SNPs being used as IVs; Significant P was marked in bold; MR, Mendelian randomization; SNP, single-nucleotide polymorphism; IV, instrumental variable; IVW, inverse-variance weighted; WM, weighted median; OR, odds ratio; CI, confidence interval; PFDR, P value corrected by false discovery rate (FDR). SNP: single nucleotide polymorphism; T2DN, type 2 diabetic nephropathy; T1DN, type 1 diabetic nephropathy. The bold values refer to the P-values still less than 0.05 after FDR correction.