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. 2024 Mar 25;22:191. doi: 10.1186/s12964-024-01565-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Glomerular endothelial CXCR2 knockout restores renal function in DKD mice. A Schematic of the experiment. Kidney-related indicators included (B) the urine albumin-to-creatinine ratio (UACR), (C) Kidney weight/body weight (KW/BW), (D) blood urea nitrogen (BUN), and (E) serum creatinine (Scr) were measured (n = 8 per group). Quantification of cross-sectional area of glomerular with hematoxylin and eosin (HE). F Periodic acid-Schiff (PAS)-stain was used for quantifing mesangial matrix fraction (G). H Representative images of HE staining in kidneys. I Representative images of PAS-stained kidneys (× 400; Scale bar = 50 μm, n = 3 mice,five randomly glomeruli were selected per mouse). Results are expressed as mean ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001 vs. CXCR2 ^L/L group; ^# P < 0.05,^## P < 0.01 and ^### P < 0.001 vs. DKD-CXCR2 ^L/L group, ^ns P > 0.05)