Table 2.

Odds ratio for ARHL associated with genetic risk group

				Model 1		Model 2		Model 3		Model 4
Genetic risk	Total no. of participants	No. of ARHL cases	Prevalence (%)	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Low	75,322	15,453	20.52	1 (reference)		1 (reference)		1 (reference)		1 (reference)
Intermediate	225,879	52,060	23.05	1.16 (1.14–1.19)	< .001	1.15 (1.12–1.17)	< .001	1.14 (1.12–1.17)	< .001	1.14 (1.11–1.17)	< .001
High	71,499	18,477	25.84	1.36 (1.33–1.40)	< .001	1.35 (1.32–1.39)	< .001	1.34 (1.31–1.38)	< .001	1.34 (1.31–1.39)	< .001
Very high	3764	1076	28.59	1.58 (1.47–1.70)	< .001	1.55 (1.43–1.68)	< .001	1.49 (1.36–1.63)	< .001	1.49 (1.36–1.62)	< .001
perSD increase				1.12 (1.11–1.13)	< .001	1.12 (1.11–1.13)	< .001	1.12 (1.11–1.13)	< .001	1.12 (1.11–1.13)	< .001

Model 1 was adjusted by age, sex, genotype array, and PC 1 to 10

Model 2: Model 1 + education years + household income + Townsend deprivation index + number in household

Model 3: Model 2 + body mass index + height + weight + waist circumference + systolic blood pressure + diastolic blood pressure + Total cholesterol + HDL cholesterol + LDL cholesterol + Triglycerides + Creatinine + eGFR + Fasting blood glucose + HbA1c

Model 4: Model 3 + tinnitus + major chronic comorbidities (hypercholesterolemia, hypertension, heart failure, chronic kidney disease, any stroke, diabetic hypoglycemia, type 2 diabetes mellitus, and coronary artery disease)

Abbreviations: ARHL age-related hearing loss, SD standard deviation, OR odds ratio, CI confidence interval, PC principal component