Table 2.

The genetic correlations between IBD and cancers caused by LDSC in the European population

Outcomes	IBD			CD			UC
	rg	se	P	rg	se	P	rg	se	P
Oropharynx cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA
Esophageal cancer	0.057	0.036	0.110	0.042	0.034	0.217	0.054	0.043	0.214
Stomach cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA
Small bowel cancer	− 0.066	0.138	0.636	− 0.092	0.166	0.579	0.022	0.119	0.855
Colorectal cancer	− 0.032	0.045	0.476	− 0.017	0.043	0.685	− 0.030	0.053	0.566
Anus cancer	0.011	0.035	0.748	0.043	0.037	0.244	− 0.003	0.043	0.954
Liver cancer	0.035	0.100	0.727	− 0.008	0.089	0.925	0.133	0.316	0.673
Bile duct cancer	0.011	0.052	0.830	0.042	0.063	0.510	0.026	0.069	0.702
Liver cell cancer	− 0.026	0.031	0.397	− 0.031	0.030	0.310	− 0.029	0.038	0.452
Pancreatic cancer	0.038	0.045	0.395	0.002	0.044	0.974	0.052	0.050	0.299
Hodgkin lymphoma	NA	NA	NA	NA	NA	NA	NA	NA	NA
Non-Hodgkin lymphoma	− 0.026	0.033	0.417	− 0.017	0.033	0.612	− 0.044	0.038	0.250
Leukemia	− 0.056	0.046	0.225	− 0.040	0.043	0.353	− 0.020	0.053	0.714
Multiple myeloma	0.004	0.030	0.898	− 0.024	0.030	0.434	0.037	0.039	0.338
Skin melanoma cancer	0.002	0.020	0.939	0.006	0.019	0.772	0.003	0.026	0.909
Nonmelanoma skin cancer	− 0.001	0.012	0.935	0.006	0.013	0.657	− 0.004	0.016	0.790
Squamous cell cancer	0.005	0.009	0.527	0.0004	0.009	0.961	0.014	0.011	0.204
Kidney cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA
Bladder cancer	0.060	0.036	0.092	0.047	0.035	0.175	0.055	0.040	0.163
Prostate cancer	− 0.024	0.016	0.135	− 0.012	0.015	0.429	− 0.030	0.019	0.126
Cervical cancer	0.002	0.029	0.944	− 0.005	0.028	0.846	0.015	0.032	0.645
Corpus uteri cancer	− 0.064	0.062	0.306	− 0.038	0.056	0.504	− 0.088	0.080	0.270
Ovarian cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA
Lung cancer	− 0.006	0.015	0.676	− 0.002	0.014	0.877	− 0.001	0.019	0.966
Breast cancer	0.003	0.016	0.825	− 0.006	0.016	0.698	0.010	0.018	0.586
Thyroid cancer	0.010	0.035	0.779	0.037	0.037	0.321	− 0.004	0.044	0.932
Brain cancer	− 0.011	0.044	0.808	− 0.017	0.041	0.682	− 0.010	0.056	0.858

CD Crohn’s disease, IBD inflammatory bowel disease, LDSC linkage disequilibrium score regression, NA not available, UC ulcerative colitis