Fig 4.

Performance of the primary and simple models compared with three previous models. Top panel shows a comparison of the discrimination of the primary and simple models (Gupta et al) with three existing models (Bhat et al,¹³ de Jongh et al,¹⁴ and Motwani et al.²³ for CP-AKI. DeLong P<0.001 for comparison of the Gupta et al models to each of the other three models. Bottom panel shows a comparison of the study characteristics and risk factors for CP-AKI identified in the Gupta et al models versus three previous models. *In the study by Motwani et al,²³ development and validation cohorts were used, but patients were derived from two hospitals within the same integrated healthcare system. †In the study by de Jongh et al,¹⁴ female sex was associated with a higher risk of CP-AKI, whereas in the study by Bhat et al,¹³ male sex was associated with a higher risk. ‡Data on paclitaxel were not available in the current dataset. AUC=area under the curve; CI=confidence interval; CP-AKI=cisplatin associated acute kidney injury