Figure 3.

Long-term continuous cytotoxicity assessments of dexrazoxane, XK469 and their combinations with daunorubicin in rat neonatal cardiomyocytes. Cells were incubated with dexrazoxane (A), or XK469 (C) alone or in combinations with daunorubicin (B, D) for up to 48 h. Cytotoxicity was assessed by the Sytox Green. DMSO (0.1% final concentration) was present in all samples. The statistical analyses: n ≥ 4, mean ± SD, 1-way ANOVA, Dunn’s post hoc test, p ≤ .05, “c”—compared with control; “d”—compared with daunorubicin.