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TOP2B proteasomal degradation in rat neonatal cardiomyocytes. Cells were treated with increasing concentrations of dexrazoxane (DEX) (A) or XK469 (B) for 24 h. Then, TOP2 content in cells was evaluated by immunodetection. Statistical analyses: n = 3–4, mean ± SD, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “c”—compared with drug-free control.
