Skip to main content
. 2024 Mar 26;4(3):919–937. doi: 10.1158/2767-9764.CRC-23-0161

FIGURE 5.

FIGURE 5

FIGURE 5

Comparison of pulmonary healthy and diseased endothelial cells and fibroblasts characterize their distribution and tumor-specific interplays with START. A, Split t-SNE plot distribution of the four endothelial clusters identified in healthy lungs (left), Vehicle- (middle), and Unesbulin-treated tumors (right). Each color represents a defined transcriptional cluster. B, Histograms representing the percentage contribution of endothelial clusters per sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). C, Venn diagram showing common and unique GO categories/ biological processes enriched in endothelial cells from each sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). D, Heat map showing the predicted interactions between endothelial cells and START in Vehicle- (red) and Unesbulin-treated tumors (light blue). E, Heat map showing the predicted interactions between START and endothelial in Vehicle- (red) and Unesbulin-treated tumors (light blue). F, Sankey plot of the protumorigenic phenotypes promoted on START by endothelial-secreted ligands (left) and on endothelial cells by START-secreted ligands (right). G, Split t-SNE plot distribution of the fibroblast clusters identified in healthy lungs (left), Vehicle- (middle), and Unesbulin-treated tumors (right). Each color represents a defined transcriptional cluster. H, Histograms representing the percentage contribution of fibroblast clusters per sample (healthy lungs, Vehicle-, and Unesbulin-treated tumors). I, Venn diagram showing common and unique GO categories/biological processes enriched in fibroblasts from each sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). J, Heat map showing the predicted interactions between START and fibroblasts in Vehicle- (red) and Unesbulin-treated tumors (light blue). K, Heat map showing the predicted interactions between fibroblasts and START in Vehicle- (red) and Unesbulin-treated tumors (light blue). L, Sankey plot of the protumorigenic phenotypes promoted on START by fibroblast-secreted ligands (left) and on fibroblasts by START-secreted ligands (right).