TABLE 2.
Ad12-induced fragility of artificial U1 tandem arrays
| Cell line | mU1 copy no.a | Location of mU1 arrayb | % of loci scored as fragile
|
||
|---|---|---|---|---|---|
| RNU2 (17q21) | RNU1c (1p36) | mU1 array | |||
| HT1080 | 88 | 40 (71) | |||
| mU1-38 | 14 | 3q(m) | 93 | 52 (70) | 19 |
| mU1-67 | 35 | Cq(m) | 95 | 59 (85) | 14 |
| mU1-77 | 21 | Cq(t) | 92 | 56 (84) | 5 |
| mU1-96 | 45 | Cp(m) | 77 | 32 (50) | 21 |
| mU1-99 | 30 | 13q(t) | 87 | 43 (64) | 16 |
| mU1-105 | 24 | 17p(m) | 95 | 46 (70) | 27 |
| mU1-125 | 36 | Cq(t) | 96 | 63 (83) | 18 |
a
From Table 1.
b
FISH signals were mapped to chromosomes 3, 13, or 17 or to a group C chromosome. The position of the signal was further defined as in the middle (m) or telomeric region (t) of the short or long arm (p or q).
c
Numbers in parentheses indicate the percentage of cells containing at least one fragile RNU1 locus.