TABLE 3.
Summary of error rates for wild-type, E89G, M184V, and E89G/M184V RTs by class
Mutation type | Wild type
|
E89G
|
M184V
|
E89G/M184V
|
||||
---|---|---|---|---|---|---|---|---|
No. of errors | Error rate | No. of errors | Error rate | No. of errors | Error rate | No. of errors | Error rate | |
All classes | 138 | 1/17,651 | 108 | 1/24,249 | 104 | 1/27,450 | 99 | 1/12,341 |
Base substitutions | 103 | 1/11,876 | 57 | 1/23,041 | 80 | 1/17,921 | 66 | 1/9,294 |
Frameshifts | 35a | 1/40,650 | 51 | 1/30,030 | 24a | 1/69,444 | 33a | 1/21,645 |
At runs | 32 | 1/23,753 | 43 | 1/19,011 | 24 | 1/37,037 | 33 | 1/11,567 |
At non-runs | 3 | 1/222,222 | 8 | 1/89,286 | 0 | CDb | 0 | CD |
In comparison of E89G to wild type, M184V, and E89G/M184V, P values were 0.0004, 0.0003, and 0.048, respectively.
CD, cannot determine.