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. 2024 Mar 21;15(2):298–308. doi: 10.14740/wjon1578

Table 2. Five Chemotherapy Regimens Developed.

1 PC Paclitaxel 135 mg/m2 on the first day, intravenously, drip for 3 h, cisplatin 50 mg on the second day, intraperitoneally with 200 mL of saline, paclitaxel 65 mg/m2 on the eighth day, intraperitoneally with 200 mL of saline. Interval: 21 days.
2 GemCap + С (intraperitoneally) Gemzar 800 mg/m2, intravenously on the first and eighth days; cisplatin 50 mg intraperitoneally per 200 mL of saline on the fourth day; capecitabine 1,500 mg/m2 for 14 days. Interval: 21 days.
3 TPFL (modification DCF) with intraperitoneal insertion of cisplatin Docetaxel 75 mg/m2 intravenously over 1 h on the second day; cisplatin 50 mg intravenously, 1 h on the second day; cisplatin 50 mg intraperitoneally per 200 mL saline on the third day; 5-FU 500 mg/m2 3-h infusion on the 1 - 3 days; leucovorin 50 mg intravenously, on the 1 - 3 days before 5-FU insertion. Interval: 21 days.
4 FOLFIRI + С (intraperitoneally) Irinotecan 170 mg/m2 intravenously, infusion 90 min; leucovorin 400 mg/m2 intravenously, infusion 2 h on the first day; 5-FU 400 mg/m2 intravenously, then 2,400 mg/m2 intravenously, infusion 46 h. Cisplatin 50 mg intraperitoneally per 200 mL of saline on the second day. Interval: 21 days.
5 XELIRI + C (intraperitoneally) Irinotecan 230 mg/m2 intravenously, infusion 60 - 90 min, on the first day; cisplatin 50 mg intraperitoneally per 200 mL saline, on the second day; capecitabine 1,800 mg/m2 daily for 14 days. Interval: 21 days.

PC: peritoneal carcinomatosis; 5-FU: 5-fluorouracil.