Table 3. Response Rate According to Appearance of irAEs for Patients With First- and Second-Line Treatment.

	First-line			Second-line
	No toxicity (N = 33)	Toxicity (N = 62)	P overall	No toxicity (N = 31)	Toxicity (N = 42)	P overall
Response rate			< 0.001			< 0.001
CR	0 (0.00%)	12 (100%)		0 (0.00%)	3 (100%)
PR	5 (14.3%)	30 (85.7%)		2 (13.3%)	13 (86.7%)
SD	5 (26.3%)	14 (73.7%)		4 (20.0%)	16 (80.0%)
PD	17 (85.0%)	3 (15.0%)		16 (64.0%)	9 (36.0%)
NE	6 (66.7%)	3 (33.3%)		9 (90.0%)	1 (10.0%)

CR: complete response; irAEs: immune-related adverse events; NE: not evaluated; PD: progressive disease; PR: partial response; SD: stable disease.