Table 5. Combination Index Values of Afatinib When Combined With Palbociclib, Dinaciclib, Capmatinib, Dasatinib, Stattic, Ponatinib, AZD4547, Trametinib, Miransertib, Paclitaxel in Human Stomach Cancer Cell Lines.
| Combination index (CI) |
||||||
|---|---|---|---|---|---|---|
| AGS | MKN1 | NCI-N87 | ||||
| TKI combination | FBS 2% | FBS 10% | FBS 2% | FBS 10% | FBS 2% | FBS 10% |
| Afatinib + palbociclib | 0.36 | 1.02 | 0.38 | 1.89 | 1.07 | 1.31 |
| Afatinib + dinaciclib | 0.95 | 1.08 | 0.42 | 0.53 | 1.58 | 2.23 |
| Afatinib + capmatinib | 0.62 | 0.85 | 0.24 | 0.48 | 1.55 | 1.28 |
| Afatinib+ dasatinib | 0.48 | 0.46 | 0.37 | 0.23 | 1.02 | 0.90 |
| Afatinib + stattic | 0.87 | 0.86 | 0.87 | 0.68 | 1.06 | 2.60 |
| Afatinib+ ponatinib | 2.51 | 1.23 | 0.45 | 0.43 | 2.63 | 1.19 |
| Afatinib + AZD4547 | 1.32 | 1.60 | 0.20 | 1.14 | 1.69 | 1.14 |
| Afatinib+ trametinib | 0.37 | 1.11 | 0.40 | 1.16 | 1.22 | 0.8 |
| Afatinib + miransertib | 0.60 | 0.82 | 0.26 | 0.16 | 0.76 | 0.71 |
| Afatinib + paclitaxel | 0.07 | 1.20 | 1.33 | 0.41 | 1.64 | 2.04 |
TKI: tyrosine kinase inhibitor; FBS: fetal bovine serum.