Table 6. Linear Regression Analysis of the Expression of Various Receptors Against the Sensitivity of Human Stomach Cancer Cell Lines to Treatment With Various TKIs, CDK Inhibitors, STAT3 Inhibitor and a Cytotoxic Agent.
| Drugs/cell surface markers | 2% |
10% |
||||
|---|---|---|---|---|---|---|
| EGFR |
HER2 |
CD44 |
EGFR |
HER2 |
CD44 |
|
| R2 (P value) | R2 (P value) | R2 (P value) | R2 (P value) | R2 (P value) | R2 (P value) | |
| Erlotinib | 0.013 (0.830) | 0.173 (0.412) | 0.258 (0.303) | 0.089 (0.566) | 0.448 (0.146) | 0.050 (0.671) |
| Lapatinib | 0.015 (0.929) | 0.099 (0.544) | 0.90 (0.564) | 0.052 (0.663) | 0.436 (0.153) | 0.041 (0.701) |
| Neratinib | 0.003 (0.916) | 0.142 (0.461) | 0.130 (0.483) | 0.074 (0.602) | 0.206 (0.366) | 0.170 (0.417) |
| Afatinib | 0.028 (0.753) | 0.157 (0.537) | 0.154 (0.442) | 0.166 (0.422) | 0.308 (0.253) | 0.115 (0.511) |
| Palbociclib | 0.737 (0.029) | 0.004 (0.905) | 0.311 (0.250) | 0.330 (0.233) | 0.048 (0.678) | 0.255 (0.307) |
| Dinaciclib | 0.347 (0.218) | 0.038 (0.710) | 0.877 (0.006) | 0.098 (0.545) | 0.355 (0.212) | 0.161 (0.431) |
| Dasatinib | 0.399 (0.179) | 0.019 (0.797) | 0.051 (0.667) | 0.143 (0.460) | 0.076 (0.596) | 0.092 (0.558) |
| Stattic | 0.234 (0.331) | 0.050 (0.671) | 0.092 (0.560) | 0.631 (0.059) | 0.068 (0.618) | 0.001 (0.943) |
| Ponatinib | 0.384 (0.190) | 0.001 (0.952) | 0.153 (0.443) | 0.490 (0.121) | 0.003 (0.918) | 0.028 (0.752) |
| Entrectinib | 0.585 (0.076) | 0.101 (0.540) | 0.004 (0.900) | 0.448 (0.146) | 0.010 (0.850) | 0.495 (0.119) |
| AZD4547 | 0.661 (0.066) | 0.057 (0.649) | 0.307 (0.254) | 0.413 (0.169) | 0.004 (0.901) | 0.072 (0.607) |
| Trametinib | 0.259 (0.302) | 0.038 (0.710) | 0.031 (0.737) | 0.185 (0.394) | 0.050 (0.671) | 0.043 (0.693) |
| Selumetinib | 0.006 (0.883) | 0.093 (0.557) | 0.86 (0.574) | 0.032 (0.734) | 0.135 (0.473) | 0.042 (0.697) |
| Miransertib | 0.490 (0.121) | 0.027 (0.754) | 0.056 (0.651) | 0.001 (0.966) | 0.722 (0.032) | 0.231 (0.335) |
| Docetaxel | 0.008 (0.965) | 0.980 (< 0.001) | 0.16 (0.812) | 0.182 (0.399) | 0.549 (0.092) | 0.007 (0.915) |
| Paclitaxel | 0.014 (0.821) | 0.182 (0.399) | 0.219 (0.349) | 0.000 (0.995) | 0.333 (0.230) | 0.266 (0.295) |
TKI: tyrosine kinase inhibitor; EGFR: epidermal growth factor receptor; CDK: cyclin dependent kinase; HER: human epidermal growth factor receptor; STAT3: signal transducer and activator of transcription 3.