Table 2.
Two-sample Mendelian randomization estimations showing the effects of immune cell traits on the risk of pre-eclampsia/eclampsia.
| Outcomes | Exposures | Inverse-variance weighted | |||
|---|---|---|---|---|---|
| OR (95% CI) | p value | Q-statistic | p valuea | ||
| Pre-eclampsia/eclampsia | Lymphocyte absolute count | 1.53 (1.31-1.79) | 1.15E-07 | 0.001 | 9.87E-01 |
| T cell absolute count | 1.49 (1.28-1.73) | 2.73E-07 | 0.038 | 8.46E-01 | |
| CD28- CD25++ CD8+ T cell absolute count | 1.83 (1.44-2.32) | 7.11E-07 | NA | NA | |
|
| |||||
| Pre-eclampsia | Lymphocyte absolute count | 1.50 (1.28-1.77) | 9.18E-07 | 0.007 | 9.34E-01 |
| T cell absolute count | 1.47 (1.25-1.72) | 1.76E-06 | 0.096 | 7.56E-01 | |
| CD28- CD25++ CD8+ T cell absolute count | 1.nn (1.38-2.26) | 6.55E-06 | NA | NA | |
OR: odds ratio; CI: confidence interval. ap value < 0.05 indicates the presence of heterogeneity. bp value < 0.05 indicates the presence of horizontal pleiotropy.