FIG. 4.
Blocking microglial infection with antibodies against coreceptors. Monoclonal antibodies against CCR3, CCR5, and CXCR4 and a control anti-human herpesvirus 6 p41 antibody (see Materials and Methods for details) were used to block infection of cultured microglial cells with pseudotyped virus expressing the HIV-1BaL env. Three days after infection, the cells were lysed, and levels of chemiluminescence were determined and expressed as relative light units/10 s. The anti-CCR5 antibody was the only one that had an effect on infection.