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Macrophage-derived nanomaterials for the treatment of digestive system tumor.
(1) Exosomes secreted by macrophages deliver miR-21, which increases PDCD4 expression and leads to the apoptosis of gastric cancer cells. (2) circ 0008253 exosomes secreted by macrophages increase ABCG2 expression. ABCG2 transports OXA out of gastric cancer cells, leading to OXA resistance. PDCD4, Programmed cell death 4; ABCG2, ATP binding cassette subfamily G member 2; OXA, Oxaliplatin.
