Fig. 8.

The effects of simvastatin (sim; 5 µM) and amfenac (0.1 µM) on the levels of intracellular ROS with (a) or without (b) 10 pg/ml IL-1α in ARPE-19 cells. DMSO (D; 0.15%) was used as dilution control of simvastatin and amfenac, and hydroquinone (HQ) 125 µM as a positive control for ROS production. Data were collected from 3 independent experiments containing 6 samples per group in each experiment (total n = 18), and results are presented as mean ± SEM. **P < 0.01, ***P < 0.001, ****P < 0.0001, ns—not significant by Mann–Whitney U test. (Kruskal–Wallis test was performed but not presented in the Figure, a ****P < 0.0001, b ****P < 0.0001)