Fig. 9.

The effects of simvastatin (sim; 5 µM) and amfenac (0.1 µM) on the release of VEGF (a) and PEDF (b), and on the ratio of VEGF with PEDF (c) in 10 pg/ml IL-1α treated ARPE-19 cells. DMSO (D; 0.15%) was used as dilution control of simvastatin and amfenac. Data were collected from 3 independent experiments containing 4 (a, c) and 2 (b, c) samples per group in each experiment [total n = 12 (a, c) and n = 6 (b, c)], and results are presented as mean ± SEM. *P < 0.05, **P < 0.01, ns—not significant by Mann–Whitney U test. (Kruskal–Wallis test was performed but not presented in the Figure, a ***P < 0.001, b not significant, c ***P < 0.001)