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Schematic graph showing the function and heterogeneity of dermal fibroblasts. (A) Normal dermal fibroblasts are divided into two subgroups: Reticular fibroblasts and Papillary fibroblasts. (B) Fibroblasts synthesize extracellular matrix to maintain skin structure integrity. (C) Fibroblasts modulate the microenvironment of the dermis and the immune responses by secreting numerous cytokines, metabolites, and growth factors.
