Table 1.
Summary of vital genes of fibroblast in autoimmune skin diseases.
| Disease | Vital Gene | Function of gene | References |
|---|---|---|---|
| Psoriasis | SFRP2 | product pro-inflammatory cytokines | 7 |
| TNC | induce psoriasiform skin inflammation | 8 | |
| OVOL1 | aggravate psoriasis-like skin inflammation | 9 | |
| Vitiligo |
CXCL9
CXCL10 |
recruit T cell | 10, 11 |
|
CCL2
CCL8 |
promoted naïve T cell polarization into Th2 cells, and attract Th2 cells |
12 | |
| Atopic Dermatitis | COL6A51 | recruit T cell | 13 |
| COL18A11 | product type2 inflammation signal induced cytokines |
13 | |
| Scleroderma | Prx1 | product pro-inflammatory cytokines | 14 |
| LGR5 | coordinate the correct tissue organization and homeostasis |
15 | |
| SFRP2 | differentiate into myofibroblasts | 16 |