Table 2.

Annualized risks and hazard ratios of primary and secondary outcomes in the ticagrelor and clopidogrel groups

Outcomes	Ticagrelor (95% CI)	Clopidogrel (95% CI)	Hazard ratio (95% CI)	P value
Primary outcome
Any major osteoporotic fracture	0.34% (0.26–0.44%)	0.56% (0.47–0.68%)	0.60 (0.44–0.83)	0.002
Secondary outcomes
Vertebral fracture	0.06% (0.03–0.11%)	0.10% (0.06–0.15%)	0.61 (0.29–1.27)	0.19
Hip fracture	0.14% (0.10–0.21%)	0.24% (0.19–0.32%)	0.65 (0.40–1.06)	0.087
Upper limb fracture	0.15% (0.11–0.23%)	0.28% (0.22–0.36%)	0.53 (0.34–0.85)	0.008