Table 3.
Subgroup analysis examining differential effects of P2Y12 inhibitors on the risk of major osteoporotic fractures
| Subgroup | Hazard ratio | 95% Confidence interval | P value for interaction | |
|---|---|---|---|---|
| Age group | 0.80 | |||
| ≤ 65 years | 0.66 | 0.38 | 1.13 | |
| > 65 years | 0.61 | 0.41 | 0.91 | |
| Sex | 0.34 | |||
| Male | 0.53 | 0.34 | 0.82 | |
| Female | 0.71 | 0.45 | 1.13 | |
| Diabetes | 0.18 | |||
| No | 0.51 | 0.33 | 0.76 | |
| Yes | 0.81 | 0.49 | 1.35 | |
| Baseline eGFR | 0.47 | |||
| ≥ 60 mL/min | 0.67 | 0.45 | 0.99 | |
| < 60 mL/min | 0.50 | 0.29 | 0.88 | |
| Previous fracture | 0.14 | |||
| No | 0.56 | 0.39 | 0.80 | |
| Yes | 0.93 | 0.45 | 1.90 | |