Table 2.

A non-exhaustive list of data and resources offered by the National Toxicological Program to researchers and the general public with a short description

Type of resource	Name	Description
Study data	Chemical effects in biological systems (CEBS)	public data repository of toxicogenomics data, clinical data, histopathology findings, microarray and proteomics data over 2000 NTP studies permitting data integration and cross-study analysis and data query using study condition and the subject responses
	NTP report series	Rodent toxicology studies results reviewed by NTP internally. The pathology results are peer-reviewed by the Pathology Working Group (PWG). The data include toxicology (TOX) reports of short-term or sub-chronic studies, technical reports (TR) of long-term or chronic studies and results using genetically modified models (GMM), developmental and reproductive toxicology (DART) studies, immunotoxicology (IMM) studies and peer-reviewed manuscripts published in scientific journals
	NTP historical controls database	A historical summary collection of chronic animal studies and genetically modified models and DART data
Tools and resources	Developmental NeuroToxicity data integration and visualization enabling resource (DNT-DIVER)	A web-based tool to analyze, compare, and visualize multiple DNT assays
	Integrated chemical environment (ICE)	Curated TOX21 data with in silico prediction of physicochemical and ADME properties, mapped in vitro data, and IVIVE tools estimating in vivo exposure (Bell et al. 2020)
	Test method development resources	Recommended protocols, tools, and research opportunities as well as guidelines and regulatory needs (only US), supporting the development of alternative test methods
	TOX21 toolbox	It contains tools for accessing, visualizing, and analyzing quantitative high-throughput screening (qHTS) data library of 10 K. The data library, one of the largest libraries constructed ever, generated 100 million data points from ∼8500 chemicals in more than 70 high-throughput toxicity assays (Richard et al. 2021)
Pathology resources	Non-neoplastic Lesion Atlas	High-quality images of rodents’ body systems and description after exposure to environmental chemicals inducing non-cancer diseases (Schmidt 2014)
	NTP archives	Provides primary public resources for toxicological research including study collections, educational material, and training material on rodent pathology. It contains millions of histological slides and paraffin-embedded tissue blocks; 242,000 bags of formalin-preserved tissues, 74,000 frozen specimens and millions of paper data and microfiche with over 18,000 digital histopathology images

NTP National Toxicological Program, PWG Pathology Working Group, TOX toxicology, TR technical reports, GMM genetically modified models, DART developmental and reproductive toxicology, IMM immunotoxicology, ADME absorption, distribution, metabolism, excretion, IVIVE in vitro to in vivo extrapolation, qHTS quantitative high-throughput screening, CEBS Chemical Effects in Biological Systems, DNT-DIVER Developmental Neurotoxicity Data Integration and Visualization Enabling Resource, ICE Chemical Integrated Environment