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. 2024 Mar 13;6:1322012. doi: 10.3389/fgeed.2024.1322012

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Copyright © 2024 Nesbitt, Galina Pantoja, Beaton, Chen, Culbertson, Harms, Holl, Sosnicki, Reddy, Rotolo and Rice.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Breeding approach to develop the multiple generations of edited pigs for evaluation of disease resistance, phenotypical characteristics, and meat composition and quality. Multiple edited E0 animals (CD163 ^ΔE7/+) from the same elite breeding line were crossed with unedited, wild-type animals (CD163 ^+/+) to produce the heterozygous (CD163 ^ΔE7/+) E1 generation. The segregating E2 population was created by interbreeding among E1 animals. Homozygous-edited (CD163 ^ΔE7/ΔE7) and null (CD163 ^+/+) animals in the E3 generation derived from crosses between homozygous-edited and null E2 animals, respectively.