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. 2024 Mar 13;15:1327647. doi: 10.3389/fphar.2024.1327647

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Copyright © 2024 Wan, Sun, Yang, Wang, Wang, Ye, Cheng, Li, Ren and Kou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of JTQBG on the pathological progress of CIA rats. (A) Experimental procedure for evaluating the anti-arthritic effect of JTQBG. (B) Effects of different doses of JTQBG and MTX on paw inflammation at different stages. (C) Average body weight per group was measured. The arthritis index (AI) (D) and paw volume (E) were measured and calculated. (F) The ELISA assay of IL-1β in serum. (G) The ELISA assay of IL-18 in serum. Values are expressed as the mean ± SD. *p < 0.05, **p < 0.01 compared with the Normal group; #p < 0.05, ##p < 0.01 compared with the Model group; △p < 0.05, △△p < 0.01 compared with the MTX group; &p < 0.05, and&p < 0.01 compared with the JTQBG-L group.