Table 2.
Results IPO-ACA versus all other occlusions
| Outcome | Patients with IPO-ACA total (n = 11) |
Patients with ICA or MCA (M1/2) occlusions (n = 4972) |
|---|---|---|
| Functional outcomes | ||
| mRS at 90 days; median (IQR)* | 3 (1–6) | 3 (2–6) |
| Functional independence (mRS 0–2), n (%) | 4/11 (36) | 1949/4815 (41) |
| NIHSS 24–48 h after stroke; median (IQR)† | 11 (2–13) | 9 (3–17) |
| Delta-NIHSS; median (IQR)‡ | –1 (–7 to 2) | –4 (–9 to 0) |
| NIHSS improvement ≥ 4 points; n (%) | 3/9 (33) | 2427/4518 (54) |
| Radiological outcomes | ||
| eTICI score; n (%) § | ||
| 0 | 3 (33) | 749 (16) |
| 1 | 0 (0) | 121 (3) |
| 2A | 2 (22) | 825 (17) |
| 2B | 1 (11) | 1082 (23) |
| 2C | 0 (0) | 520 (11) |
| 3 | 3 (33) | 1481 (31) |
| Successful reperfusion (TICI 2B-3) | 4 (44) | 3083 (64) |
| Safety outcomes | ||
| Periprocedural perforation; n (%) ¶ | 0/9 (0) | 65/4318 (2) |
| Periprocedural dissection; n (%) †† | 0/9 (0) | 77/4330 (2) |
| Symptomatic intracranial hemorrhage; n (%) | 1/11 (9) | 294/4972 (6) |
| NIHSS deterioration ≥ 4 points; n (%) §§ | 1/9 (11) | 532/4518 (12) |
| Mortality at 90 days; n (%) | 3/11 (27) | 1263/4815 (26) |
* missing: 157; † missing: 436; ‡ missing: 456; § missing: 196; ¶ missing: 656; †† missing: 644; §§ missing: 454. Change in NIHSS from baseline to 24–48 h after stroke. ACA anterior cerebral artery, eTICI expanded thrombolysis in cerebral Infarction, IPO-ACA, isolated primary occlusion of the anterior cerebral artery, IQR, interquartile range, mRS, modified Rankin Scale, MR CLEAN, Multicenter Randomized CLinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands, NIHSS, National Institutes of Health Stroke Scale