Table 3.
Estimated incidence rate (per 100,000 person-years) and percentage of all hospitalizations attributable to RSV infections in adults by age group and year, 2016–2019, Spain
| 2016 | 2017 | 2018 | 2019 | |||||
|---|---|---|---|---|---|---|---|---|
| IR [95% CI] | % | IR [95% CI] | % | IR [95% CI] | % | IR [95% CI] | % | |
| Primary outcomes | ||||||||
| RSV-attributable cardiorespiratory hospitalizations (all respiratory + selected subgroup cardiovascular outcomes) | ||||||||
| 18–49 years | 9.1 [0.8; 17.3] | 2.4 | 8.5 [0.8; 16.0] | 2.2 | 9.1 [0.8; 17.2] | 2.2 | 9.9 [0.9; 18.7] | 2.4 |
| 50–59 years | 27.0 [5.6; 49.9] | 2.0 | 24.3 [5.1; 44.8] | 1.8 | 25.4 [5.3; 46.9] | 1.7 | 27.2 [5.7; 50.1] | 1.9 |
| 60–79 years | 149.0 [83.4; 218.7] | 2.7 | 144.7 [81.0; 212.4] | 2.6 | 156.1 [87.3; 229.1] | 2.7 | 155.2 [86.8; 227.7] | 2.8 |
| ≥ 80 years | 1361.4 [1035.9; 1696.6] | 6.5 | 1324.9 [1008.1; 1651.1] | 6.0 | 1460.9 [1111.6; 1820.6] | 6.2 | 1505.7 [1145.7; 1876.4] | 6.4 |
| ≥ 60 yearsa | 450.3 | 4.9 | 437.6 | 4.5 | 474.5 | 4.7 | 475.8 | 4.8 |
| RSV-attributable respiratory hospitalizations | ||||||||
| 18–49 years | 5.1 [0; 11,5] | 2.1 | 4.8 [0; 10,7] | 1.9 | 5.1 [0; 11,4] | 1.9 | 5.5 [0; 12,4] | 2.1 |
| 50–59 years | 18.2 [7.1; 29.2] | 3.2 | 16.4 [6.4; 26.3] | 2.9 | 17.1 [6.7; 27.5] | 2.8 | 18.3 [7.1; 29.4] | 3.1 |
| 60–79 years | 114.5 [85.4; 145.2] | 5.8 | 116.0 [86.5; 147.1] | 5.8 | 130.9 [97.6; 165.9] | 6.1 | 125.8 [93.8; 159.4] | 6.1 |
| ≥ 80 years | 702.5 [540.4; 871.0] | 9.5 | 683.6 [525.9; 847.7] | 8.7 | 753.8 [579.9; 934.7] | 8.9 | 776.9 [597.7; 963.3] | 9.4 |
| ≥ 60 yearsa | 260.7 | 7.8 | 256.9 | 7.4 | 282.9 | 7.7 | 280.4 | 7.9 |
| Subgroup outcomes | ||||||||
| RSV-attributable influenza or pneumonia hospitalizations | ||||||||
| 18–49 years | 0.7 [0; 3.2] | 1.3 | 0.8 [0; 3.4] | 1.6 | 0.9 [0; 4.1] | 1.6 | 0.9 [0; 4.0] | 1.5 |
| 50–59 years | 1.6 [0; 7.8] | 1.1 | 1.5 [0; 7.0] | 1.0 | 1.5 [0; 7.3] | 0.9 | 1.6 [0; 7.8] | 1.0 |
| 60–79 years | 36.4 [25.3; 46.8] | 7.3 | 36.8 [25.6; 47.4] | 7.0 | 41.5 [28.9; 53.5] | 7.1 | 39.9 [27.8; 51.4] | 7.0 |
| ≥ 80 years | 229.1 [176.3; 283.5] | 11.8 | 223.0 [171.5; 275.9] | 9.8 | 245.9 [189.1; 304.2] | 10.2 | 253.4 [194.9; 313.5] | 10.9 |
| ≥ 60 yearsa | 84.3 | 9.8 | 83.0 | 8.7 | 91.4 | 8.8 | 90.6 | 9.2 |
| RSV attributable bronchitis or bronchiolitis hospitalizations | ||||||||
| 18–49 years | 1.3 [0.6; 2.1] | 6.9 | 1.3 [0.6; 2.1] | 6.2 | 1.4 [0.6; 2.2] | 5.9 | 1.5 [0.6; 2.4] | 6.7 |
| 50–59 years | 8.3 [5.6; 11.1] | 10.6 | 8.1 [5.4; 10.8] | 9.7 | 8.8 [5.9; 11.7] | 8.7 | 8.8 [5.9; 11.8] | 9.3 |
| 60–79 years | 46.1 [37.0; 55.9] | 13.2 | 46.7 [37.5; 56.6] | 12.1 | 52.7 [42.2; 63.9] | 12.2 | 50.6 [40.6; 61.4] | 12.5 |
| ≥ 80 years | 270.4 [217.4; 331.8] | 16.4 | 263.1 [211.5; 322.9] | 13.4 | 290.1 [233.2; 356.1] | 13.7 | 299.0 [240.4; 367.0] | 14.7 |
| ≥ 60 yearsa | 101.8 | 15.2 | 100.4 | 12.9 | 110.6 | 13.1 | 109.6 | 13.8 |
| RSV-attributable chronic lower respiratory disease hospitalizations | ||||||||
| 18–49 years | 3.1 [1.6; 4.7] | 5.8 | 2.9 [1.5; 4.4] | 5.1 | 3.1 [1.6; 4.7] | 5.1 | 3.4 [1.7; 5.1] | 5.8 |
| 50–59 years | 14.1 [8.5; 19.6] | 5.8 | 12.7 [7.6; 17.6] | 5.2 | 13.2 [8.0; 18.4] | 5.0 | 14.2 [8.5; 19.6] | 5.7 |
| 60–79 years | 58.0 [41.8; 75.7] | 5.5 | 58.8 [42.4; 76.7] | 5.5 | 66.3 [47.8; 86.5] | 6.0 | 63.7 [45.9; 83.2] | 6.0 |
| ≥ 80 years | 213.5 [160.2; 271.2] | 7.6 | 207.7 [155.9; 263.9] | 7.0 | 229.1 [171.9; 291.0] | 7.5 | 236.1 [177.1; 299.9] | 7.9 |
| ≥ 60 yearsa | 96.7 | 6.5 | 95.8 | 6.2 | 106.0 | 6.7 | 104.7 | 6.9 |
| RSV-attributable upper respiratory disease hospitalizations | ||||||||
| 18–49 years | 1.3 [0; 6.0] | 1.2 | 1.2 [0; 5.6] | 1.1 | 1.3 [0; 6.0] | 1.1 | 1.4 [0; 6.5] | 1.2 |
| 50–59 years | 1.8 [0; 6.2] | 1.9 | 1.6 [0; 5.6] | 1.6 | 1.7 [0; 5.8] | 1.6 | 1.8 [0; 6.3] | 1.8 |
| 60–79 years | 2.8 [0; 6.2] | 2.4 | 2.6 [0; 5.6] | 2.1 | 2.7 [0; 5.8] | 2.1 | 2.8 [0; 6.1] | 2.2 |
| ≥ 80 years | 18.4 [13.0; 23.9] | 10.4 | 17.9 [12.7; 23.2] | 9.2 | 19.7 [14.0; 25.6] | 9.8 | 20.3 [14.4; 26.4] | 10.3 |
| ≥ 60 yearsa | 6.7 | 5.1 | 6.4 | 4.5 | 6.8 | 4.7 | 7.0 | 4.9 |
| RSV-attributable chronic heart failure exacerbation hospitalizations | ||||||||
| 18–49 years | 1.1 [0.5; 1.7] | 4.9 | 1.0 [0.4; 1.6] | 4.2 | 1.1 [0.5; 1.7] | 4.5 | 1.2 [0.5; 1.8] | 4.6 |
| 50–59 years | 6.2 [2.9; 9.6] | 4.1 | 5.6 [2.6; 8.6] | 3.5 | 5.8 [2.8; 9.0] | 3.6 | 6.2 [3.0; 9.6] | 3.8 |
| 60–79 years | 24.9 [13.6; 36.2] | 2.8 | 24.1 [13.2; 35.2] | 2.7 | 26.0 [14.3; 37.9] | 2.9 | 25.9 [14.2; 37.7] | 2.9 |
| ≥ 80 years | 277.4 [208.4; 353.9] | 6.0 | 270.0 [202.8; 344.4] | 5.5 | 297.7 [223.6; 379.7] | 5.7 | 306.8 [230.4; 391.4] | 5.8 |
| ≥ 60 yearsa | 87.6 | 4.8 | 85.1 | 4.5 | 92.3 | 4.7 | 92.6 | 4.8 |
| RSV-attributable ischemic heart disease hospitalizations | ||||||||
| 18–49 years | NA | NA | NA | NA | NA | NA | NA | NA |
| 50–59 years | 2.4 [0; 8.0] | 0.8 | 2.2 [0; 7.2] | 0.7 | 2.3 [0; 7.5] | 0.7 | 2.4 [0; 8.0] | 0.8 |
| 60–79 years | 26.7 [12.4; 41.1] | 2.8 | 24.0 [11.2; 37.1] | 2.5 | 24.9 [11.6; 38.4] | 2.5 | 26.3 [12.2; 40.6] | 2.7 |
| ≥ 80 years | 92.4 [61.0; 128.4] | 4.0 | 89.9 [59.4; 124.9] | 3.7 | 99.1 [65.5; 137.8] | 4.0 | 102.2 [67.5; 142.0] | 4.2 |
| ≥ 60 yearsa | 43.0 | 3.3 | 40.4 | 3.0 | 43.0 | 3.2 | 44.3 | 3.4 |
| RSV-attributable arrythmias hospitalizations | ||||||||
| 18–49 years | NA | NA | NA | NA | NA | NA | NA | NA |
| 50–59 years | 6.0 [1.1; 11.2] | 3.1 | 5.4 [1.0; 10.1] | 2.7 | 5.6 [1.0; 10.6] | 2.8 | 6.0 [1.1; 11.3] | 2.9 |
| 60–79 years | 29.0 [11.2; 47.1] | 2.5 | 26.1 [10.1; 42.4] | 2.2 | 27.1 [10.4; 44.0] | 2.2 | 28.6 [11.0; 46.4] | 2.4 |
| ≥ 80 years | 272.5 [198.1; 345.2] | 5.4 | 265.2 [192.8; 335.9] | 4.9 | 292.4 [212.6; 370.4] | 5.1 | 301.3 [219.1; 381.8] | 5.2 |
| ≥ 60 yearsa | 89.5 | 4.2 | 85.4 | 3.9 | 91.8 | 4.0 | 93.3 | 4.1 |
| RSV-attributable cerebrovascular hospitalizations | ||||||||
| 18–49 years | NA | NA | NA | NA | NA | NA | NA | NA |
| 50–59 years | NA | NA | NA | NA | NA | NA | NA | NA |
| 60–79 years | 10.3 [3.7; 17.0] | 2.2 | 9.3 [3.3; 15.3] | 1.9 | 9.7 [3.5; 15.9] | 2.0 | 10.2 [3.7; 16.8] | 2.0 |
| ≥ 80 years | 20.9 [4.3; 37.6] | 1.4 | 18.9 [3.8; 33.9] | 1.2 | 20.0 [4.1; 36.0] | 1.3 | 21.9 [4.5; 39.4] | 1.4 |
| ≥ 60 yearsa | 13.0 | 1.8 | 11.7 | 1.6 | 12.2 | 1.6 | 13.0 | 1.7 |
Myocarditis outcome was NA in all categories
CI confidence interval, IR incidence rate, NA not applicable since data is unsuitable for modeling or insufficient model fit
aBased on pooling of results for models fitted to adults, thus confidence intervals are not provided. Negative estimates were suppressed to zero because of biological implausibility