Table 2.

Comparisons of spectral domain-optical coherence tomography measures in eyes of optic nerve hypoplasia patients and controls.

	ONH patients (n = 17)	Controls (n = 34)	Univariable analysis			Multivariable analysisb
			Estimate	95% CI	p valuea	Estimate	95% CI	p valuea
pRNFL thickness (μm)
Average	65.19 ± 30.77	103.31 ± 7.99	−38.121	−55.853, −20.390	0.0001	−39.173	−56.906, −21.441	< 0.0001
Superior	75.50 ± 33.21	125.29 ± 14.07	−49.794	−69.802, −29.787	< 0.0001	−49.905	−71.629, −28.180	< 0.0001
Temporal	63.63 ± 39.08	90.88 ± 15.80	−27.257	−49.812, −4.703	0.0201	−29.269	−51.352, −7.185	0.0106
Inferior	88.69 ± 41.84	124.94 ± 17.87	−36.254	−60.236, −12.272	0.0039	−37.333	−60.121, −14.545	0.0017
Nasal	33.19 ± 21.79	72.41 ± 15.34	−39.224	−52.810, −25.639	< 0.0001	−40.237	−52.136, −28.338	< 0.0001
ST	96.00 ± 40.25	145.26 ± 24.20	−49.265	−73.442, −25.087	0.0001	−51.504	−76.649, −23.360	0.0001
SN	54.06 ± 28.44	107.41 ± 16.23	−53.349	−71.352, −35.347	< 0.0001	−53.203	−72.437, −33.969	< 0.0001
IT	114.25 ± 50.27	144.44 ± 29.42	−30.191	−60.429, 0.047	0.0503	−31.578	−62.839, −0.317	0.0477
IN	63.00 ± 36.36	98.76 ± 26.79	−35.765	−56.916, −14.613	0.0014	−36.238	−56.607, −15.869	0.0007

ONH optic nerve hypoplasia; n numbers; pRNFL peripapillary retinal nerve fiber layer; ST superotemporal; SN superonasal; IT inferotemporal; IN inferonasal; CI confidence interval.

Values are shown as mean ± standard deviation.

Estimate and 95% CI were calculated by Generalized Estimating Equation (GEE).

^ap value was calculated by Benjamini-Hochberg correction for multiple outcomes.

^bMultivariable analysis with adjustment for age and spherical equivalent refractive errors.

Bold value indicates p < 0.05.