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. 2024 Mar 26;14:7132. doi: 10.1038/s41598-024-56932-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Angiocrine activity of APC-secreted LEP (a) LEPR silencing inhibited the proliferative effect of hypoxic APC-CM on HUVECs. *p < 0.05 and ***p < 0.001 versus EGM2 ^#p < 0.05 versus scramble. (b) LEPR silencing abolished the promotion of HUVEC network formation by hypoxic APC-CM. *p < 0.05 versus EGM2 ^#p < 0.05 versus scramble. (c) Blockade of LEP signalling increases the vascular resistance of HUVEC monolayers exposed to hypoxic APC-CM. ***p < 0.001 versus control.