Table 5.
RNA modifications in lipid, amino acid and mitochondrial metabolism
| Regulator | Disease | Target | Mechanism | Ref. |
|---|---|---|---|---|
| Lipid metabolism | ||||
| METTL3 | Obesity | FASN | Upregulates its mRNA level | 284 |
| CCND1 | Promotes degradation of CCND1 mRNA via YTHDF2 | 285 | ||
| FTO | RUNX1T1 | Controls the exonic splicing by regulating the RNA binding ability of SRSF2 | 288 | |
| CCNA2/CDK2 | Reduces the YTHDF2-mediated decay of mRNA | 289,290 | ||
| YTHDF1 | MTCH2 | Facilitate its translation | 296 | |
| METTL3/14 | NAFLD | ACLY/SCD1 | Upregulates the expression | 299 |
| METTL3 | Rubicon | Promotes Rubicon expression via YTHDF1 | 300 | |
| FTO | SREBP1/SCD1 | Upregulates the expression via m6A demethylation | 303 | |
| IL-17RA | Upregulates its expression via m6A demethylation | 307 | ||
| ALKBH5 | LINC01468 | Stabilizes LINC01468 to promote degradation of INPPL1 | 308 | |
| PTCH1 | promotes its expression via m6A demethylation | 309 | ||
| YTHDF3 | PRDX3 | Facilitates its translation | 310 | |
| METTL14 | AS | p65 | Promotes the expression of p65 | 314 |
| lncRNA ZFAS1 | Downregulates ZFAS1 level | 315 | ||
| FTO | PPARγ | Downregulates expression level of PPARγ and promotes phosphorylation of AMPK | 317 | |
| METTL14 | BLCA | PPARs | METTL14 elevates level of lncDBETm, which interacts with FABP5 to activate PPARs | 321 |
| - | BRCA/HCC | CPT1B | Elevated m6A level triggers the splicing of precursor ESRRG mRNA to improve ERRγ, which upregulate CPT1B | 323 |
| METTL5 | HCC | ACSL4 | Promotes ACSL4-mediated FAO | 324 |
| FTO | HCC | FASN | Protects the mRNA from YTHDF2-mediated decay | 325 |
| FTO | EC | HSD17B11 | Enhances its translation | 326 |
| ALKBH5 | CESC | ACC1 | Attenuates IGF2BP1-mediated stabilization of SIRT3, further reduces ACC1 level by repressing its deacetylation | 327 |
| YTHDF2 | GBM | LXRA/HIVEP2 | Facilitates decay of mRNAs to suppress cholesterol synthesis, efflux, and uptake | 329 |
| CRC | DEGS2 | Mediates its degradation to induce lipidomic dysregulation | 330 | |
| IGF2BP2 | AML | MFSD2A | Stabilizes PRMT6 mRNA to suppress MFSD2A expression | 331 |
| HNRNPA2B1 | GC | RPRD1B | Stabilizes the transcripts | .332 |
| ESCA | ACLY/ACC1 | Promotes the expression | 333 | |
| NSUN2 | OS | FABP5 | Stabilizes the transcripts | 335 |
| TRMT6/TRMT61A | HCC | PPARδ | Facilitates its translation | 337 |
| Mitochondrial metaboliam | ||||
| FTO | ccRCC | PGC-1α | Upregulates its expression | 341 |
| METTL3 | NSCLC | DCP2 | Accelerates its degradation | 342 |
| BRCA | AK4 | Upregulates AK4 to ROS production and p38 phosphorylation | 343 | |
| METTL14 | CRC | miR-17-5p | Induces degradation of miR-17-5p via YTHDC2, which downstream suppress MFN2 | 345 |
| IGF2BP1 | GC | NDUFA4 | Upregulates NDUFA via stabilization to enhance oxidative metabolism | 224 |
| IGF2BP2 | GBM | SHMT2 | Stabilizes its mRNA to promote OXPHOS | 350 |
| RALY | CRC | ETC-related genes | Augments processing of pri-miRNA to further downregulate ETC-related genes | 352 |
| Amino acid metabolism | ||||
| FTO | ccRCC | SLC1A5 | Promotes its expression | 357 |
| CRC | ATF4 | Upregulates ATF4 to activate DDIT4, and then suppress mTOR signaling | 358 | |
| YTHDF1 | CRC | GLS | induces translational promotion of GLS | 360 |
| IGF2BP2 | AML | GPT2/SLC1A5/MYC | Enhances mRNA stability and translation of several glutamine metabolism-related genes | 361 |
| METTL16 | AML | BCAT1/2 | Facilitates its expression to regulate branched-chain amino acid metabolism | 363 |