Table 4.
Polygenic risk scores of ulcerative colitis (PRSUC) and Crohn’s disease (PRSCD) as predictors of progression-free survival (PFS) and overall survival (OS) in the GeRI cohort, using Cox proportional hazards models
| PFS | OS | |||||
|---|---|---|---|---|---|---|
| PRS | HR per SD | 95% CI | p-value | HR per SD | 95% CI | p-value |
| PRSUC | 1.00 | 0.94–1.07 | 0.99 | 1.01 | 0.93–1.09 | 0.91 |
| PRSCD | 0.98 | 0.91–1.05 | 0.50 | 1.02 | 0.93–1.11 | 0.68 |
All p-values are two-sided.
All models are adjusted for age at diagnosis, sex, histology, type of therapy, recruiting site, and 5 principal components.
PRS polygenic risk score, PFS progression-free survival, OS overall survival, HR hazards ratio, SD standard deviation, CI confidence interval, UC ulcerative colitis, CD Crohn’s disease.