Figure S4.

Statistical analysis of IL-18 and IL-1β secretion in reconstituted U937 upon NLRP3 expression, priming, and/or activation. RC heatmap from the lmm modeling for each variant as compared with the WT. Positive RC denotes increased cytokine concentrations by the variant as compared to NLRP3 WT, and conversely. RC corresponding to statistically significant increases (magenta) or decreases (cyan) in cytokine secretions are color-coded (P < 0.05, and RC > +1 or RC < −1, respectively). Not significant variations are color-coded in gray (P > 0.05). Results of 3–18 independent experiments done in duplicates (as indicated for each variant on the right side).