Table 2.

Diagnostic criteria

Normal physical examination

No history of congenital thrombocytopenia

No alterations at the blood smear apart from thrombocytopenia

Bone marrow aspirate morphology: compatible with isolated thrombocytopenia

Absence of autoimmunity markers (anti-nucleus, anti-thyroglobulin, and anti-thyroid peroxidase antibodies; anti-cardiolipin and anti–β2-glycoprotein antibodies; and Lupus anticoagulant) and direct anti-globulin test

Normal coagulation parameters

Normal serum biochemistry: glucose, urea, creatinine, uric acid, bilirubin, AST, ALT, alkaline phosphatase, LDH, sodium, potassium, calcium, total proteins and electrophoresis, and albumin

Absence of lymphadenopathies; liver and spleen enlargement

Absence of neoplasms

Absence of acute or chronic infectious diseases

ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase.