. 2023 Dec 15;11(2):748–758. doi: 10.1002/ehf2.14603

Table 4.

CMR cardiac morphology, function, and tissue characterization

Parameter	Control group (n = 22) (controls)	HIV‐infected ART‐naïve (n = 73) (ART‐naïve)	P value ^a	HIV‐infected 9 months on ART (n = 73) (ART)	P value ^b	Change (Δ) in HIV group over time (n = 73)
LA area (cm²)	20.0 ± 3.1	20.2 ± 3.9	0.8	21.0 ± 3.8	0.05	0.7 ± 3.1
RA area (cm²)	18.9 ± 3.1	19.6 ± 3.8	0.4	20.4 ± 3.4	0.01	0.7 ± 2.5
LV mass indexed to height (g/m)	60 (51–71)	63 (53–73)	0.05 ^c	63 (53–74)	0.8	4 (−3 to 11)
LV end‐diastolic volume indexed to height (mL/m)	81 ± 13	86 ± 16	0.03 ^d	89 ± 15	0.008	4 ± 12
LV sphericity index	0.53 ± 0.04	0.53 ± 0.05	0.6	0.52 ± 0.04	0.4	0 ± 0.03
LV ejection fraction (%)	63 ± 5	60 ± 6	0.03	59 ± 5	0.6	0 ± 5
Global native T1 mapping (ms)	1008 ± 31	1032 ± 44	0.02	1014 ± 34	<0.001	−18 ± 38
Global T2 mapping (ms)	46 ± 1.6	48 ± 2.7	0.006	48 ± 2.1	0.5	0 ± 2
Global ECV index (%)	24 ± 2.8 ^e	26 ± 4.1	0.1	25 ± 3.1	0.001	−1.5 ± 3.7
LGE present	1 (10%) ^e	35 (49%)	0.02	40 (55%)	0.2	—
Pattern of LGE
Subepicardial	—	18 (50%)	—	18 (45%)	0.7	—
Midmyocardial	1 (100%) ^e	12 (33%)	—	17 (43%)	—	—
Mixed	—	6 (17%)	—	5 (12%)	—	—

ART, antiretroviral therapy; CMR, cardiovascular magnetic resonance imaging; ECV, extracellular volume; HIV, human immunodeficiency virus; LA, left atrial; LGE, late gadolinium enhancement; LV, left ventricular; RA, right atrial.

Continuous variables are mean ± standard deviation or median (inter‐quartile range) unless otherwise specified. P values in bold indicate statistical significance.

^{^a}

Controls vs. ART naïve group

^{^b}

ART‐naïve group vs. ART group.

^{^c}

Mean difference = 6 g when corrected for age, sex, race, estimated glomerular filtration rate, and current tuberculosis.

^{^d}

Mean difference = 6 mL when corrected for age, sex, race, ethanol use, and current tuberculosis.

^{^e}

Fifty per cent of the controls received gadolinium contrast (n = 11).