TABLE 2.
Cox regression univariate and multivariate analysis for DFS on the entire group of 1257 patients
| Univariate | Multivariate (all variables) | |
|---|---|---|
| DFS | HR (95% CI) | HR (95% CI) |
| Age (y) | P=.057 | P=.43 |
| ≤45 | 1.00 | 1.00 |
| >45 | 1.44 (0.99–2.11) | 1.17 (0.79–1.74) |
| Stage | P=.003 | P=.055 |
| 1b1 | 1.00 | 1.00 |
| 2a1 | 2.39 (1.34–4.25) | 1.85 (0.99–3.39) |
| LVSI | P<.0001 | P=.004 |
| No | 1.00 | 1.00 |
| Yes | 2.38 (1.58–3.57) | 1.81 (1.16–2.82) |
| Unknown | 0.90 (0.48–1.68) | 0.74 (0.39–1.39) |
| Grade | P=.044 | P=.34 |
| 1 | 1.00 | 1.00 |
| 2 | 1.72 (0.75–3.94) | 1.68 (0.72–3.94) |
| 3 | 2.60 (1.08–6.23) | 1.96 (0.79–4.85) |
| Histology | P=.002 | P=.002 |
| SCC | 1.00 | 1.00 |
| Adenocarcinoma | 1.02 (0.66–1.58) | 1.43 (0.90–2.26) |
| Other | 2.58 (1.51–4.40) | 2.61 (1.51–4.48) |
| Adjuvant therapy | P<.0001 | P=.95 |
| No | 1.00 | 1.00 |
| Yes | 2.01 (1.38–2.92) | 0.97 (0.63–1.50) |
| Diameter | P<.0001 | P<.0001 |
| ≤20 mm | 1.00 | 1.00 |
| 21–40 mm | 3.25 (2.17–4.87) | 2.99 (1.96–4.59) |
| Radicality of RH | P=.049 | P=.004 |
| Nerve sparing | 1.00 | 1.00 |
| Non-nerve sparing | 0.63 (0.40–0.99) | 0.50 (0.31–0.81) |
CI, confidence interval; DSF, disease-free survival; HR, hazard ratio; LVSI, lymphovascular space invasion; RH, radical hysterectomy; SCC, squamous cell carcinoma.