Table 3.

Multivariable analyses via logistic regression.

Outcomes	BMI group (ref=normal)	OR	95 % CI	P-value*
CAC >0	Underweight	2.8	(1.8, 4.3)	<0.001
	Overweight	1.2	(0.9, 1.6)	0.2
	Class I obesity	1.0	(0.6, 1.7)	0.9
	Class II obesity	1.0	(0.6, 1.8)	0.9
	Class III obesity	1.0	(0.7, 1.4)	0.9
hsCRP ≥2 mg/L	Underweight	30.1	(17.7, 51.1)	<0.001
	Overweight	1.9	(1.4, 2.8)	<0.001
	Class I obesity	0.7	(0.4, 1.3)	0.2
	Class II obesity	1.6	(0.8, 3.0)	0.2
	Class III obesity	0.9	(0.7, 1.4)	0.8
PHQ-9 $\ge$5	Underweight	2.5	(1.5, 4.1)	<0.001
	Overweight	1.5	(1.0, 2.0)	0.02
	Class I obesity	1.2	(0.7, 2.1)	0.5
	Class II obesity	1.2	(0.7, 2.2)	0.5
	Class III obesity	1.0	(0.7, 1.5)	0.9
GAD-7 $\ge$10	Underweight	1.7	(1.0, 2.8)	0.04
	Overweight	1.3	(0.9, 1.9)	0.09
	Class I obesity	1.6	(0.9, 2.9)	0.1
	Class II obesity	0.8	(0.4, 1.5)	0.5
	Class III obesity	1.4	(0.9, 2.1)	0.1
Mean step count ≥4000	Underweight	0.3	(0.2, 0.5)	<0.001
	Overweight	0.7	(0.6, 1.0)	0.02
	Class I obesity	0.9	(0.6, 1.5)	0.7
	Class II obesity	1.5	(0.9, 2.4)	0.1
	Class III obesity	0.7	(0.5, 1.0)	0.03

*All models were adjusted for enrollment age, sex, ethnicity, race, current smoking status, and enrollment site. The rationale for cut-offs for the above outcomes is as follows: a CAC score >0 suggests some coronary plaque; an hsCRP level of 3 or higher suggests a high risk for cardiovascular events; a mean PHQ-9 score of 5 or higher suggests depression; a mean GAD-7 score of 10 or higher suggests general anxiety disorder; and a mean step count of 4000 is the average step count for Americans. CAC, coronary artery calcium; CI, confidence interval; GAD-7, General Anxiety Disorder-7; hsCRP, high-sensitivity C-reactive protein; OR, odds ratio; PHQ-9, Patient Health Questionnaire-9.