Figure 1.
Top panels: Exemplary mouse brain single-voxel (SPECIAL (35) with outer-volume suppression (36); 3 × 6 × 5 mm3 nominal dimensions) 2H MR spectra for data summed over the first 70 minutes following sc administration of, from left to right, Glc, Act, and βHB substrates. Each substrate was administered as a ~40-sec bolus of a 1-M solution (in saline), at a dose of 25μL/g-body-weight. A 10-Hz line broadening exponential apodization function was applied to the time-domain data prior to Fourier transformation. The intensities observed in these MR spectra are resonance amplitudes and not metabolite concentrations. Bottom panels: Frequency-domain representation of the Bayesian-estimated time-domain model (37–39) of the data shown in the top panel.