TABLE 2.
Mouse brain-passaged BDV retains potential to induce neurological diseasea
| Mouse strain | BDV passage no. | No. of mice | No. (%) of mice with neurological symptoms | Age (days) at onset of symptoms |
|---|---|---|---|---|
| BALB/c | 1 | 7 | 4 (57) | 29–45 |
| BALB/c | 2 | 11 | 4 (36) | 28–35 |
| BALB/c | 3 | 19 | 10 (52) | 23–31 |
| BALB/c | 4 | 7 | 3 (43) | 26–33 |
| MRL | 2 | 12 | 11 (91) | 27–42 |
Neonates were given intracerebral injections of 10-μl samples of stocks of BDV He/80 that were passaged for the indicated times in brains of BALB/c mice.